Results 151 to 160 of about 23,738,827 (303)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

[Stage Two Landscapes 19]

, 2003
Wet on wet landscape with white, tan and red buildings, green trees in foreground, blue and red sky.Tiff file: 2440x3280 pixels, 22.9 Mb; Display: jpeg, 595x800 pixels ...
Father Edward Catich
core  

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

[Stage Two Landscapes 17]

, 2003
Wet on wet landscape with black and white houses and trees; green, rust and yellow foreground; blue and grey sky.Tiff file: 2030x3280 pixels, 19 Mb; Display: jpeg, 495x800 pixels ...
Father Edward Catich
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

[Stage Two Landscapes 09]

, 2003
Wet on wet landscape of many buildings in blue, green, red and white; 2 figures along water and dock with grey, green and blue sky.Tiff file: 2280x3380 pixels, 22.0 Mb; Display: jpeg, 525x800 pixels ...
Father Edward Catich
core  

Pragmatic Two-Stage Design for Clinical Trials With Treatment Selection. [PDF]

Stat Med
Horton P, Mei Y.
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Two-Stage Management of Early Intrapelvic Cup Migration. [PDF]

Arthroplast Today
Ghanimeh J, Yammine K, Otayek J, El Alam A, Hayek F, Samaha C, Assi C.   +6 more
europepmc   +1 more source