Results 91 to 100 of about 373,972 (292)

Bounded Risk Estimation of the Gamma Scale Parameter in a Purely Sequential Sampling Procedure

Journal of Statistical Theory and Applications (JSTA)
We consider the purely sequential procedure for estimating the scale parameter of a gamma distribution with known shape parameter, when the risk function is bounded by the known preassigned number.
Eisa Mahmoudi, Ghahraman Roughani, Ashkan Khalifeh   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Estimation of Parameters of Non-stationary Geophysical Signals Based on Two-Stage Approximations Using Local Models

Russian Journal of Earth Sciences
The authors have developed a technology for estimating the parameters of non-stationary geophysical signals, using a two-stage approximation with local approximation models at the first stage and weighted averaging at the second stage.
Getmanov Viktor, Gvishiani Alexei, Pilipenko Vyacheslav, Stukov D. A.   +3 more
doaj   +1 more source

A Two-Stage Framework for Distortion Information Estimation and Underwater Image Restoration

Photonics
This work introduces a two-stage framework, named the Distorted underwater image Restoration Network (DR-Net), to address the complex degradation of underwater images caused by turbulence, water flow fluctuations, and optical properties of water.
Jianming Liu, Congzheng Wang, Chuncheng Feng, Lei Liu, Wanqi Gong, Zhibo Chen, Libin Liao, Chang Feng   +7 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Sleep Stage Estimation Comparing Own Past Heartrate or Others' Heartrate

SICE Journal of Control, Measurement, and System Integration, 2018
To increase the accuracy of real-time sleep stage estimation when only a small number of sleep data can be obtained such as after going to bed, the information for the subject's own sleep and other's past sleep can be used.
Yusuke Tajima, Fumito Uwano, Akinori Murata, Tomohiro Harada, Keiki Takadama   +4 more
doaj   +1 more source

New Methods for Two‐Stage Treatment Switching Estimation

Pharmaceutical Statistics
ABSTRACTTreatment switching is common in randomized trials of oncology treatments. For example, control group patients may receive the experimental treatment as a subsequent therapy. One possible estimand is the effect of trial treatment if this type of switching had instead not occurred.
Dan Jackson, Di Ran, Fanni Zhang, Mario Ouwens, Vitaly Druker, Michael Sweeting, Robert Hettle, Ian R. White   +7 more
openaire   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source