Results 81 to 90 of about 1,685,973 (289)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Two Stage Estimation in Semiparametric Model

DEStech Transactions on Materials Science and Engineering, 2017
Considering the semi-parametric surveying adjustment models. Firstly, the estimators of parameters and nonparametric are derived by using the kernel function and least square method. Secondly, discuss the approach of bandwidth choice in the semi-parametric surveying adjustment models.
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Two-Stage Kalman Filter for Fault Tolerant Estimation of Wind Speed and UAV Flight Parameters

Measurement Science Review, 2020
In this study, an estimation algorithm based on a two-stage Kalman filter (TSKF) was developed for wind speed and Unmanned Aerial Vehicle (UAV) motion parameters. In the first stage, the wind speed estimation algorithm is used with the help of the Global
Hajiyev Chingiz, Cilden-Guler Demet, Hacizade Ulviye   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Two-Stage Marker Detection–Localization Network for Bridge-Erecting Machine Hoisting Alignment

Sensors
To tackle the challenges of complex construction environment interference (e.g., lighting variations, occlusion, and marker contamination) and the demand for high-precision alignment during the hoisting process of bridge-erecting machines, this paper ...
Lei Li, Zelong Xiao, Taiyang Hu
doaj   +1 more source

Estimation under two stage random permutation models

Metrika, 1985
In a simple two-stage random permutation model the units which have fixed but unknown values \(x_{ij}\) of the study variate x, are labelled randomly in two stages, first the psu's are labelled at random and then the ssu's within each of the psu's are labelled at random independently.
Mukhopadhyay, P., Padmawar, V.R.
openaire   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

RELIABILITY BIVARIATE ANALYSIS BASED ON COPULAS ANÁLISIS BIVARIADO DE CONFIABILIDAD BASADO EN CÓPULAS

Revista Colombiana de Estadística, 2011
In industry, reliability studies are done to assure the quality level of products manufactured. Sometimes these products have several failure modes that must be considered in reliability analysis.
Monjardin Pedro Enrique, Villa-Diharce Enrique Raúl   +1 more
doaj  

Semantic Attention Guided Hierarchical Decision Network for Age Estimation

Applied Sciences
Image-based human age estimation has been a hot topic in the field of face attribute recognition. As the greatest dilemma of age estimation is the similar appearance of adjacent age labels, this paper presents a two-stage age estimation model based on ...
Xincheng Qiao, Chunlong Hu, Bin Qin
doaj   +1 more source