Results 71 to 80 of about 683,782 (308)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Two-Stage Maximum Score Estimator
, 2020 This paper considers the asymptotic theory of a semiparametric M-estimator that is generally applicable to models that satisfy a monotonicity condition in one or several parametric indexes. We call the estimator two-stage maximum score (TSMS) estimator since our estimator involves a first-stage nonparametric regression when applied to the binary choice
Gao, Wayne Yuan, Xu, Sheng, Xu, Kan
openaire +2 more sources
MEASURING THE PERFORMANCE OF TWO-STAGE PRODUCTION SYSTEMS WITH SHARED INPUTS BY DATA ENVELOPMENT ANALYSIS [PDF]
As a non-parametric technique in Operations Research and Economics, Data Envelopment Analysis (DEA) evaluates the relative efficiency of peer production systems or decision making units (DMUs) that have multiple inputs and outputs.
A.B. Jaafar +3 more
core
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
MRIE: Enhanced Rainfall Intensity Estimation With Two-Stage Multimodal Deep Learning
IEEE AccessAccurate rainfall intensity estimation is crucial for environmental monitoring and urban planning. However, the reliability of existing methods in practical applications is relatively low due to certain deficiencies in data processing and noise ...
Jin Li, Wentao Hu, Zhigang Zhou
doaj +1 more source
Estimating and explaining efficiency in a multilevel setting: A robust two-stage approach [PDF]
Various applications require multilevel settings (e.g., for estimating fixed and random effects). However, due to the curse of dimensionality, the literature on non-parametric efficiency analysis did not yet explore the estimation of performance drivers ...
De Witte, K., Verschelde, M.
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Identification and estimation of sequential English auctions [PDF]
Brendstrup (2007) and Brendstrup and Paarsch (2006) claim that sequential English auction models with multi-unit demand can be identified from the distribution of the last stage winning price and without any assumption on bidding behavior in the earliest
Laurent Lamy
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Testing Categorized Bivariate Normality With Two-Stage Polychoric Correlation Estimates [PDF]
(WP 10/03 Clave pdf) We show that when the thresholds and the polychoric correlation are estimated in two stages, neither Pearson´s X² nor the likelihood ratio G² goodness of fit test statistics are asymptotically chi-square.We propose a new test ...
ALBERTO MAYDEU
core