Results 71 to 80 of about 22,687,746 (256)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Two-Stage Batch Algorithm for Nonlinear Static Parameter Estimation
, 2020 A two-stage batch estimation algorithm for solving a class of nonlinear, static parameter estimation problems that appear in aerospace engineering applications is proposed.
Gebre-Egziabher, Demoz, Kerry, Sun
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Revista Colombiana de Estadística, 2011 In industry, reliability studies are done to assure the quality level of products manufactured. Sometimes these products have several failure modes that must be considered in reliability analysis.
Monjardin Pedro Enrique +1 more
doaj
Identification and estimation of sequential English auctions [PDF]
Brendstrup (2007) and Brendstrup and Paarsch (2006) claim that sequential English auction models with multi-unit demand can be identified from the distribution of the last stage winning price and without any assumption on bidding behavior in the earliest
Laurent Lamy
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Two-Stage Marker Detection–Localization Network for Bridge-Erecting Machine Hoisting Alignment
SensorsTo tackle the challenges of complex construction environment interference (e.g., lighting variations, occlusion, and marker contamination) and the demand for high-precision alignment during the hoisting process of bridge-erecting machines, this paper ...
Lei Li, Zelong Xiao, Taiyang Hu
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Semantic Attention Guided Hierarchical Decision Network for Age Estimation
Applied SciencesImage-based human age estimation has been a hot topic in the field of face attribute recognition. As the greatest dilemma of age estimation is the similar appearance of adjacent age labels, this paper presents a two-stage age estimation model based on ...
Xincheng Qiao, Chunlong Hu, Bin Qin
doaj +1 more source
Estimating and explaining efficiency in a multilevel setting: A robust two-stage approach [PDF]
Various applications require multilevel settings (e.g., for estimating fixed and random effects). However, due to the curse of dimensionality, the literature on non-parametric efficiency analysis did not yet explore the estimation of performance drivers ...
De Witte, K., Verschelde, M.
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