Results 71 to 80 of about 1,685,973 (289)

Two-Stage Estimation for Ultrahigh Dimensional Sparse Quadratic Discriminant Analysis

Journal of Mathematics
The conventional Quadratic Discriminant Analysis (QDA) encounters a significant hurdle due to parameter scaling complexities on the order of Op2, rendering it impractical for the analysis of high or ultrahigh dimensional data. This arises especially when
Shengbin Zhou, Yejin Huang, Xiue Gao
doaj   +1 more source

Inference for Two-Stage Extremum Estimators

SSRN Electronic Journal
We present a simulation-based inference approach for two-stage estimators, focusing on extremum estimators in the second stage. We accommodate a broad range of first-stage estimators, including extremum estimators, high-dimensional estimators, and other types of estimators such as Bayesian estimators.
Houndetoungan, Aristide, Maoude, Abdoul Haki   +1 more
openaire   +2 more sources

Estimating Reference Ranges from Stratified Two-stage Samples

Journal of the Royal Statistical Society Series A: Statistics in Society, 2001
Summary We present methodology for estimating age-specific reference ranges by using data from two-stage samples. On the basis of the information obtained in the first stage, the initial sample is stratified and random subsamples are drawn from each stratum, where the selection probabilities in this second-stage sampling may be different
Thompson, Mary Lou, Edland, Steven D., Gibbons, Laura E., McCurry, Susan M.   +3 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Dynamic panel regression with fuzzy outputs: A two-stage estimation framework

Systems and Soft Computing
Traditional panel data models, while effective in managing longitudinal and cross-sectional variations, are not suitable for handling imprecise data in real-world scenarios caused by vagueness, subjectivity or measurement limitations.
Gholamreza Hesamian, Arne Johannssen
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Parameterization and Two-Stage Conditional Maximum Likelihood Estimation [PDF]

, 1985
This paper considers the case where, after appropriate reparameterization, the probability density function can be factorized into a marginal density function and a conditional density function such that one of them involves fewer parameters.
Lien, Da-Hsiang Donald, Vuong, Quang H.
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

MRIE: Enhanced Rainfall Intensity Estimation With Two-Stage Multimodal Deep Learning

IEEE Access
Accurate rainfall intensity estimation is crucial for environmental monitoring and urban planning. However, the reliability of existing methods in practical applications is relatively low due to certain deficiencies in data processing and noise ...
Jin Li, Wentao Hu, Zhigang Zhou
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source