Results 61 to 70 of about 683,782 (308)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Evaluation algorithm for continuous time-delay-Doppler channel parameters of UAVs in 5G-A communication-sensing scenarios

Dianzi Jishu Yingyong
Aiming at the severe threat of unmanned aerial vehicle (UAV) “black flight” to the safe operation of substations, as well as the problems of low positioning accuracy, weak anti-interference ability and poor scene adaptability of traditional low-altitude ...
Ma Baichao, Wang Qingze, Sun Bin, Wang Tianyu   +3 more
doaj   +1 more source

A sampling plan for residentially generated solid waste quantification at urban zones of middle sized cities

Revista Facultad de Ingeniería Universidad de Antioquia, 2013
We propose a sampling plan intended for medium size cities. The proposed plan begins with a two-stage pilot plan, which helped us to obtain a better estimation of the final sample size when a ratio estimator is used.
Rafael A Klinger, Javier Olaya, Luis Marmolejo, Carlos Madera   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Two-Stage Estimation for Ultrahigh Dimensional Sparse Quadratic Discriminant Analysis

Journal of Mathematics
The conventional Quadratic Discriminant Analysis (QDA) encounters a significant hurdle due to parameter scaling complexities on the order of Op2, rendering it impractical for the analysis of high or ultrahigh dimensional data. This arises especially when
Shengbin Zhou, Yejin Huang, Xiue Gao
doaj   +1 more source

Two-Stage Experiments for Estimating a Common Mean

The Annals of Mathematical Statistics, 1960
class of "best" estimators, it is shown in this paper that supeRn(O, m) -) lLas n -4 oo if and only if m/n - O and m-+ oo as n oo; that minm supoRn(O, m) 1 + Cnt* as n oo; and that the minimax sample size is m Cn1 as n - oo. 1. Introduction. This investigation treats the problem of estimating the common mean , of two populations using a fixed number n ...
openaire   +3 more sources

TWO-STAGE QUANTILE REGRESSION WHEN THE FIRST STAGE IS BASED ON QUANTILE REGRESSION [PDF]

We present the asymptotic properties of double-stage quantile regression estimators with random regressors, where the first stage is based on quantile regressions with the same quantile as in the second stage, which ensures robustness of the estimation ...
Tae-Hwan Kim, Christophe Muller
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Dynamic panel regression with fuzzy outputs: A two-stage estimation framework

Systems and Soft Computing
Traditional panel data models, while effective in managing longitudinal and cross-sectional variations, are not suitable for handling imprecise data in real-world scenarios caused by vagueness, subjectivity or measurement limitations.
Gholamreza Hesamian, Arne Johannssen
doaj   +1 more source