Results 121 to 130 of about 22,687,746 (256)

Improving multi-talker binaural DOA estimation by combining periodicity and spatial features in convolutional neural networks

EURASIP Journal on Audio, Speech, and Music Processing
Deep neural network-based direction of arrival (DOA) estimation systems often rely on spatial features as input to learn a mapping for estimating the DOA of multiple talkers.
Reza Varzandeh, Simon Doclo, Volker Hohmann   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Two-Stage Decoupling Framework for Blind Hyperspectral Unmixing: Separately Refining Endmembers and Abundances

Remote Sensing
Hyperspectral unmixing (HU) aims to estimate endmembers and their corresponding abundances, a task commonly referred to as blind hyperspectral unmixing (BLU). Nonnegative matrix factorization (NMF) provides a unified framework for their joint estimation.
Hengnuo Liu, Yulin Zhang, Yanyan Li, Yongli Wang, Xiuchuan Chen   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

On two-stage estimation of structural instrumental variable models. [PDF]

Biometrika, 2017
Choi BY, Fine JP, Brookhart MA.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

MAJORITY DECODER OF CYCLIC CODE WITH TWO-STAGE ESTIMATION OF RELIABILITY OF INFORMATION

Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019
The efficiency two-stage majority decoding algorithm for cyclic codes in the correction of error of multiplicity binary symbols where - the number of test equations, needed to guarantee the correction of erroneous symbols is studied. The conditions under
A. I. Korolev, V. K. Konopelko, N. A. Salas, E. G. Makeichik, K. I. Pirogov   +4 more
doaj  

Two-stage estimation to adjust for treatment switching in randomised trials: a simulation study investigating the use of inverse probability weighting instead of re-censoring. [PDF]

BMC Med Res Methodol, 2019
Latimer NR, Abrams KR, Siebert U.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Housing Demand with Random Group Effects [PDF]

This paper examines the random group effect, which has usually not been considered in traditional housing demand studies. Frequently, group level variables are used in housing demand estimation due to the data constraint.
Sue-Jing Lin, Wen-chieh Wu
core