Results 121 to 130 of about 1,685,973 (289)

Improving multi-talker binaural DOA estimation by combining periodicity and spatial features in convolutional neural networks

EURASIP Journal on Audio, Speech, and Music Processing
Deep neural network-based direction of arrival (DOA) estimation systems often rely on spatial features as input to learn a mapping for estimating the DOA of multiple talkers.
Reza Varzandeh, Simon Doclo, Volker Hohmann   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Estimating and explaining efficiency in a multilevel setting: A robust two-stage approach [PDF]

Various applications require multilevel settings (e.g., for estimating fixed and random effects). However, due to the curse of dimensionality, the literature on non-parametric efficiency analysis did not yet explore the estimation of performance drivers ...
De Witte, K., Verschelde, M.
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A two-stage randomized response technique for simultaneous estimation of sensitivity and truthfulness

Scientific Reports
Privacy protection is a critical concern when dealing with sensitive survey questions. Conventional randomized response (RR) models frequently fall short in providing respondents with adequate secrecy when assessing important parameters like the ...
Shehzad Ahmad Khan, Mohammed Ahmed Alomair, Moiz Qureshi, Abdullah Mohammed Alomair   +3 more
doaj   +1 more source

A simple two-stage carrier-phase estimation algorithm for 32-QAM coherent optical communication systems

Frontiers in Physics
The combination of high-order modulation formats and linewidth-tolerant carrier phase estimation (CPE) can effectively improve spectrum efficiency and relax the limitation of laser linewidth.
Min Peng, Xiangqing Wang, Xiangqing Wang, Xiangqing Wang, Xiangqing Wang, Xiangqing Wang, Xiaokun Yang, Xiaokun Yang, Dongfei Wang, Dongfei Wang   +9 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Exact Local Whittle Estimation of Fractionally Cointegrated Systems [PDF]

Semiparametric estimation of a bivariate fractionally cointegrated system is considered. We propose a two-step procedure that accommodates both (asymptotically) stationary (d =1/2) stochastic trend and/or equilibrium error. A tapered version of the local
Shimotsu, Katsumi
core  

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Habits, Complementarities and Heterogenenity in Alcohol and Tobacco Demand: A Multivariate Dynamic Model [PDF]

In this paper we test the existence of rational habit formation in a multivariate model for alcohol and tobacco consumption. The theoretical framework, based on a dynamic adjustment cost model with forward-looking behaviour, is enhanced to include the ...
David Aristei, Luca Pieroni
core