MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
On two-stage estimation of structural instrumental variable models. [PDF]
Biometrika, 2017 Choi BY, Fine JP, Brookhart MA.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Two-stage estimation to adjust for treatment switching in randomised trials: a simulation study investigating the use of inverse probability weighting instead of re-censoring. [PDF]
BMC Med Res Methodol, 2019 Latimer NR, Abrams KR, Siebert U.
europepmc +1 more source
Limited Information Estimation and Testing of Discretized Multivariate Normal Structural Models [PDF]
(WP03/03 Clave pdf) We consider the estimation of multivariate normal structural models that have been discretized according to a set of thresholds. A popular estimation procedure for this restricted multinomial model consists in the following three ...
ALBERTO MAYDEU
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
MAJORITY DECODER OF CYCLIC CODE WITH TWO-STAGE ESTIMATION OF RELIABILITY OF INFORMATION
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 The efficiency two-stage majority decoding algorithm for cyclic codes in the correction of error of multiplicity binary symbols where - the number of test equations, needed to guarantee the correction of erroneous symbols is studied. The conditions under
A. I. Korolev +4 more
doaj
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
An Estimator of Variance for Two-Stage Ratio Regression Estimators [PDF]
Forest Science, 2014 Steen Magnussen +2 more
openaire +1 more source
Housing Demand with Random Group Effects [PDF]
This paper examines the random group effect, which has usually not been considered in traditional housing demand studies. Frequently, group level variables are used in housing demand estimation due to the data constraint.
Sue-Jing Lin, Wen-chieh Wu
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