Results 41 to 50 of about 788,535 (301)

Convex Combination of Ordinary Least Squares and Two-stage Least Squares Estimators

, 2015
In the presence of confounders, the ordinary least squares (OLS) estimator is known to be biased. This problem can be remedied by using the two-stage least squares (TSLS) estimator, based on the availability of valid instrumental variables (IVs). This reduction in bias, however, is offset by an increase in variance.
Ginestet, Cedric E., Emsley, Richard, Landau, Sabine   +2 more
openaire   +2 more sources

Asymptotic normality and consistency of a two-stage generalized least squares estimator in the growth curve model

, 2008
Let $\mathbf{Y}=\mathbf{X}\bolds{\Theta}\mathbf{Z}'+\bolds{\mathcal {E}}$ be the growth curve model with $\bolds{\mathcal{E}}$ distributed with mean $\mathbf{0}$ and covariance $\mathbf{I}_n\otimes\bolds{\Sigma}$, where $\bolds{\Theta}$, $\bolds{\Sigma}$
Hu, Jianhua, Yan, Guohua
core   +1 more source

Local RBF approximation for scattered data fitting with bivariate splines [PDF]

, 2005
In this paper we continue our earlier research [4] aimed at developing effcient methods of local approximation suitable for the first stage of a spline based two-stage scattered data fitting algorithm.
A. Björck, A. Iske, H. Wendland, J.R. McMahon, K. Jetter, L.L. Schumaker, M.S. Floater, O. Davydov, R. Schaback, R. Schaback   +9 more
core   +2 more sources

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Drift and Diffusion in Panel Data: Extracting Geopolitical and Temporal Effects in a Study of Passenger Rail Traffic

Computer Sciences & Mathematics Forum
Two-stage least squares (2SLS) regression undergirds much of contemporary geospatial econometrics. Walk-forward validation in time-series forecasting constitutes a special instance of iterative local regression.
James Ming Chen, Thomas Poufinas, Angeliki C. Panagopoulou   +2 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The hidden economic costs of air pollution in China: evidence from remotely sensed nighttime light data

GIScience & Remote Sensing
While the negative health consequences of air pollution exposure are well documented, its effects on economic activities remain less understood. Existing empirical studies often focus on the impacts of air pollution on production-related economic ...
Han-Su Zhang, Nan Xu, Shiyi Zhang, Wei Hu, Chenghao Deng, Yue Chang, Zeyu Zhang, Yifu Ou   +7 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source