Results 71 to 80 of about 1,005,829 (270)

Application of a Multi-Criterion Decision-Making Method for Solving the Multi-Objective Optimization of a Two-Stage Helical Gearbox

Machines
This paper provides a novel application of a multi-criterion decision-making (MCDM) method to the multi-objective optimization problem of designing a two-stage helical gearbox.
Van-Thanh Dinh, Huu-Danh Tran, Duc-Binh Vu, Duong Vu, Ngoc-Pi Vu, Anh-Tung Luu   +5 more
doaj   +1 more source

Multi-Channel Attention Selection GAN with Cascaded Semantic Guidance for Cross-View Image Translation

, 2019
Cross-view image translation is challenging because it involves images with drastically different views and severe deformation. In this paper, we propose a novel approach named Multi-Channel Attention SelectionGAN (SelectionGAN) that makes it possible to
Corso, Jason J., Sebe, Nicu, Tang, Hao, Wang, Yanzhi, Xu, Dan, Yan, Yan   +5 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

A two-stage approach to enhancing biofuel supply chains through predictive and optimization analytics

Supply Chain Analytics
The escalating pressures of population growth, surging global energy needs, water shortages, reliance on fossil fuels, and urban air pollution underscore the critical demand for sustainable energy alternatives.
Mehdi Soltani Tehrani, Siamak Noori, Ehsan Dehghani   +2 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Improving the Energy Efficiency of the ATAD System through Redesign using Integration Superstructure

Chemical Engineering Transactions, 2018
The aim of this study is application of an approach for solution of two-stage stochastic optimization problem for design of heat-integrated Autothermal Thermophilic Aerobic Digestion (ATAD) bioreactors system for municipal wastewater treatment operating ...
Rayka K. Vladova, Natasha Gr. Vaklieva-Bancheva, Elisaveta G. Kirilova   +2 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Identifying Optimal Approaches to Early Termination in Two-Stage Biomarker Validation Studies

Journal of the Royal Statistical Society Series C: Applied Statistics, 2016
SummaryGroup sequential study designs have been proposed as an approach to conserve resources in biomarker validation studies. Typically, group sequential study designs allow both ‘early termination to reject the null hypothesis’ and ‘early termination for futility’ if there is evidence against the alternative hypothesis.
Kaizer, Alexander M., Koopmeiners, Joseph S.   +1 more
openaire   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Multi-objective optimization and decision visualization of batch stirred tank reactor based on spherical catalyst particles

Nonlinear Analysis, 2019
This paper presents a Bayesian approach rooted algorithm oriented to the properties of multi-objective optimization problems. The performance of the developed algorithm is compared with several other multi-objective optimization algorithms.
Antanas Žilinskas, Romas Baronas, Linas Litvinas, Linas Petkevičius   +3 more
doaj   +3 more sources