Results 71 to 80 of about 1,008,660 (269)

Application of a Multi-Criterion Decision-Making Method for Solving the Multi-Objective Optimization of a Two-Stage Helical Gearbox

Machines
This paper provides a novel application of a multi-criterion decision-making (MCDM) method to the multi-objective optimization problem of designing a two-stage helical gearbox.
Van-Thanh Dinh, Huu-Danh Tran, Duc-Binh Vu, Duong Vu, Ngoc-Pi Vu, Anh-Tung Luu   +5 more
doaj   +1 more source

Multi-Channel Attention Selection GAN with Cascaded Semantic Guidance for Cross-View Image Translation

, 2019
Cross-view image translation is challenging because it involves images with drastically different views and severe deformation. In this paper, we propose a novel approach named Multi-Channel Attention SelectionGAN (SelectionGAN) that makes it possible to
Corso, Jason J., Sebe, Nicu, Tang, Hao, Wang, Yanzhi, Xu, Dan, Yan, Yan   +5 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A two-stage approach to enhancing biofuel supply chains through predictive and optimization analytics

Supply Chain Analytics
The escalating pressures of population growth, surging global energy needs, water shortages, reliance on fossil fuels, and urban air pollution underscore the critical demand for sustainable energy alternatives.
Mehdi Soltani Tehrani, Siamak Noori, Ehsan Dehghani   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Improving the Energy Efficiency of the ATAD System through Redesign using Integration Superstructure

Chemical Engineering Transactions, 2018
The aim of this study is application of an approach for solution of two-stage stochastic optimization problem for design of heat-integrated Autothermal Thermophilic Aerobic Digestion (ATAD) bioreactors system for municipal wastewater treatment operating ...
Rayka K. Vladova, Natasha Gr. Vaklieva-Bancheva, Elisaveta G. Kirilova   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Identifying Optimal Approaches to Early Termination in Two-Stage Biomarker Validation Studies

Journal of the Royal Statistical Society Series C: Applied Statistics, 2016
SummaryGroup sequential study designs have been proposed as an approach to conserve resources in biomarker validation studies. Typically, group sequential study designs allow both ‘early termination to reject the null hypothesis’ and ‘early termination for futility’ if there is evidence against the alternative hypothesis.
Kaizer, Alexander M., Koopmeiners, Joseph S.   +1 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Multi-objective optimization and decision visualization of batch stirred tank reactor based on spherical catalyst particles

Nonlinear Analysis, 2019
This paper presents a Bayesian approach rooted algorithm oriented to the properties of multi-objective optimization problems. The performance of the developed algorithm is compared with several other multi-objective optimization algorithms.
Antanas Žilinskas, Romas Baronas, Linas Litvinas, Linas Petkevičius   +3 more
doaj   +3 more sources