Results 81 to 90 of about 341,237 (307)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Spectral-Efficiency of TDD Multiuser Two-Hop MC-CDMA Systems Employing Egocentric-Altruistic Relay Optimization [PDF]

, 2010
In this contribution we investigate the spectral-efficiency of a two-hop cooperative network using multicarrier code-division multiple-access (MC-CDMA) transmission scheme.
Tingting Liu, Yang, Lie-Liang, Lie-Liang Yang, Chenyang Yang, Liu, Tingting, Yang, Chenyang   +5 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Application of a Multi-Criterion Decision-Making Method for Solving the Multi-Objective Optimization of a Two-Stage Helical Gearbox

Machines
This paper provides a novel application of a multi-criterion decision-making (MCDM) method to the multi-objective optimization problem of designing a two-stage helical gearbox.
Van-Thanh Dinh, Huu-Danh Tran, Duc-Binh Vu, Duong Vu, Ngoc-Pi Vu, Anh-Tung Luu   +5 more
doaj   +1 more source

Improving the Energy Efficiency of the ATAD System through Redesign using Integration Superstructure

Chemical Engineering Transactions, 2018
The aim of this study is application of an approach for solution of two-stage stochastic optimization problem for design of heat-integrated Autothermal Thermophilic Aerobic Digestion (ATAD) bioreactors system for municipal wastewater treatment operating ...
Rayka K. Vladova, Natasha Gr. Vaklieva-Bancheva, Elisaveta G. Kirilova   +2 more
doaj   +1 more source

A novel optimization approach to forest height reconstruction from multi-baseline data [PDF]

, 2007
The paper deals with the problem of reconstructing the height of forests from polarimetric/multi-baseline SAR data. The approach consists of optimizing an objective functional defined as the distance between the measured data and the data predicted ...
K.P. Papathanassiou, K. P. PAPATHANASSIOU, A. Liseno, A. Capozzoli, D'ELIA, GIUSEPPE, Liseno, A., Moreira, A., LISENO, ANGELO, Papathanassiou, K.P., G. D'Elia, D’Elia, G., CAPOZZOLI, AMEDEO, Capozzoli, A., A. MOREIRA   +13 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Modelling and solution methods for stochastic optimisation [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.In this thesis we consider two research problems, namely, (i) language constructs for modelling stochastic programming (SP) problems and (ii) solution ...
Zverovich, Victor
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Stability analysis of two stage stochastic mathematical programs with complementarity constraints via NLP-regularization [PDF]

This paper presents numerical approximation schemes for a two stage stochastic programming problem where the second stage problem has a general nonlinear complementarity constraint: first, the complementarity constraint is approximated by a parameterized
Xu, Huifu, Lin, Gui-Hua, Liu, Yongchao
core