Results 101 to 110 of about 1,020,088 (291)
A Two-Stage Optimization Approach for Healthcare Facility Location- Allocation Problems With Service Delivering Based on Genetic Algorithm. [PDF]
Int J Public Health, 2023 Salami A, Afshar-Nadjafi B, Amiri M.
europepmc +1 more source
Neither Global Nor Local: A Hierarchical Robust Subspace Clustering For Image Data
, 2019 In this paper, we consider the problem of subspace clustering in presence of contiguous noise, occlusion and disguise. We argue that self-expressive representation of data in current state-of-the-art approaches is severely sensitive to occlusions and ...
Abdolali, Maryam, Rahmati, Mohammad
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Operations Research PerspectivesThe occurrence of sequential droughts and various forms of water shortages globally underscores the urgent need for sustainable water management solutions.
Mohammad Sadeghi, Saeed Yaghoubi
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Efficient Motion Planning Algorithm for Stochastic Dynamic Systems with Constraints on Probability of Failure [PDF]
, 2008 When controlling dynamic systems such as mobile robots in uncertain environments, there is a trade off between risk and reward. For example, a race car can turn a corner faster by taking a more challenging path.
Ono, Masahiro, Williams, Brian C.
core +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Two-stage robust optimization approach for enhanced community resilience under tornado hazards
European Journal of Operational ResearchCatastrophic tornadoes cause severe damage and are a threat to human wellbeing, making it critical to determine mitigation strategies to reduce their impact. One such strategy, following recent research, is to retrofit existing structures. To this end, in this article we propose a model that considers a decision-maker (a government agency or a public ...
Mehdi Ansari +2 more
openaire +3 more sources