Results 111 to 120 of about 341,237 (307)
MULTI-OBJECTIVE OPTIMIZATION IN AXIAL COMPRESSOR DESIGN USING A LINKED CFD-SOLVER [PDF]
, 2008 In combination with a multi-objective 3D optimization strategy, a linked CFD-solver is introduced in this paper, combining 3D-Reynolds-averaged-Navier-Stokes and an inviscid through-flow method.
Lawerenz, Martin +2 more
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Optimal pattern of technology adoption under embodiment with a finite planning horizon : A multi-stage optimal control approach [PDF]
By deriving the necessary conditions for a multi-stage discounted optimal control problem where the endogenous switching instants between regimes appear as an argument of the objective function and the state equation, we analyze the optimal pattern of ...
Huseyin cagri SAGLAM
core
Quadratic two-stage stochastic optimization with coherent measures of risk [PDF]
, 2017 A new scheme to cope with two-stage stochastic optimization problems uses a risk measure as the objective function of the recourse action, where the risk measure is defined as the worst-case expected values over a set of constrained distributions.
Li-Zhi Liao +7 more
core +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Operations Research PerspectivesThe occurrence of sequential droughts and various forms of water shortages globally underscores the urgent need for sustainable water management solutions.
Mohammad Sadeghi, Saeed Yaghoubi
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Animals’ Health Control Efficiency in Northwest Portugal: A Two-stage DEA Approach [PDF]
A two-stage approach is employed to analyze the efficiency of cooperatives responsible for ruminants’ disease control (OPP) at the farm level in Northwest Portugal.
Silva, Elvira +2 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source