Results 101 to 110 of about 124,244 (302)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Constraint Programming based column generation approach to nurse rostering problems [PDF]

open access: yes, 2012
This paper presents our investigations on a hybrid constraint programming based column generation (CP–CG) approach to nurse rostering problems. We present a complete model to formulate all the complex real-world constraints in several benchmark nurse ...
He, F., Qu, R.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Multistage Stochastic Portfolio Optimisation in Deregulated Electricity Markets Using Linear Decision Rules [PDF]

open access: yes
The deregulation of electricity markets increases the financial risk faced by retailers who procure electric energy on the spot market to meet their customers’ electricity demand.
Paula Rocha, Daniel Kuhn
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Approximation in stochastic integer programming [PDF]

open access: yes
Approximation algorithms are the prevalent solution methods in the field of stochastic programming. Problems in this field are very hard to solve. Indeed, most of the research in this field has concentrated on designing solution methods that approximate ...
Vlerk, Maarten H. van der, Stougie, Leen
core   +1 more source

Closed Types as a Simple Approach to Safe Imperative Multi-Stage Programming [PDF]

open access: yes, 2000
. Safely adding computational eects to a multi-stage language has been an open problem. In previous work, a closed type constructor was used to provide a safe mechanism for executing dynamically generated code.
Moggi, Eugenio,   +5 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

A two-stage productivity analysis using bootstrapped Malmquist index and quantile regression [PDF]

open access: yes
This paper examines the effects of farm characteristics and government policies in enhancing productivity growth for a sample of Greek farms, using a two-stage procedure.
Nitsi, Elisavet I., Kaditi, Eleni A.
core   +1 more source

Derivation of near-optimal pump schedules for water distribution by simulated annealing [PDF]

open access: yes, 2004
The scheduling of pumps for clean water distribution is a partially discrete non-linear problem with many variables. The scheduling method described in this paper typically produces costs within 1% of a linear program-based solution, and can incorporate ...
Powell, R S, McCormick, G
core  

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