Results 101 to 110 of about 746,046 (294)
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Specifying a consistent joint maximum-likelihood (JMLE) approach to testing bond models [PDF]
, 1996 In this paper we extend the results derived in our earlier work to develop a methodology to employ the maximum-likelihood estimation technique for the pricing of interest rate instruments.
Ramamurtie, B. Sailesh, Ulman, Scott
core
Remanufacturing planning under uncertainty: a two-stage stochastic programming approach
, 2016 A multi-product multi-period aggregate remanufacturing planning problem involving uncertain input data is considered. A two-stage stochastic programming approach is investigated, resulting in the formulation of a large-size linear program. Preliminary computational results providing a first assessment of the value of stochastic programming for the ...
Gicquel, Céline +2 more
openaire +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Budgetary policies and available actions: a generalisation of decision rules for allocation and research decisions [PDF]
The allocation problem in health care can be characterised as a mathematical programming problem but attempts to incorporate uncertainty in costs and effect have suffered from important limitations.
Claire McKenna +3 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A dynamic day-ahead paratransit planning problem [PDF]
We consider a dynamic planning problem for the transport of elderly and disabled people. The focus is on a decision to make one day ahead: which requests to serve with own vehicles, and which ones to assign to subcontractors, under uncertainty of late ...
Cremers, Marloes +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Introductory Problem Solving in Computer Science [PDF]
, 1997 This paper describes our experiences in devising a lightweight, informal methodology for problem solving in introductory, university level, computer science.
Barnes, David J. +2 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source