Results 91 to 100 of about 746,046 (294)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A Two-Stage Stochastic Programming Approach for Energy-Oriented Lot-Sizing

We consider an industrial plant equipped with an on-sitepower generation system based on intermittent renewable energy. Weinvestigate the problem of simultaneously planning the industrial productionand the energy supply in this plant on a short-therm horizon.We propose to handle the resulting energy-oriented lot-sizing problem bya two-stage scenario ...
Liao, Ruiwen, Quezada, Franco, Gicquel, Céline, Kedad-Sidhoum, Safia   +3 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Non-parametric liquidity-adjusted VaR model: a stochastic programming approach [PDF]

This paper proposes a Stochastic Programming (SP) approach for the calculation of the liquidity-adjusted Value-at-Risk (LVaR). The model presented in this paper offers an alternative to Almgren and Chriss’s mean-variance approach (1999 and 2000). In this
Fragnière, Emmanuel, Gondzio, Jacek, Tuchschmid, Nils, Zhang, Qun   +3 more
core  

Semi-Automated Programming of Industrial Robotic Systems Using Large Language Models and Standardized Data Model

Robotics
The increasing application of industrial robots in modern production systems contrasts with a persistently high programming complexity that requires specialized know-how and creates substantial entry barriers.
Daniel Syniawa, Levin Droste, Bernd Kuhlenkötter   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

On the Dynamic Programming approach to economic models governed by DDE's [PDF]

In this paper a family of optimal control problems for economic models is considered, whose state variables are driven by Delay Differential Equations (DDE's).
Fabbri, Giorgio, Faggian, Silvia, Gozzi, Fausto   +2 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A novel scenario planning approach considering criteria interaction in multi-criteria evaluation: An application to urban mobility [PDF]

Decision Science Letters
This study proposes a new scenario planning approach which consists of two main stages: evaluating scenarios under multiple criteria and selecting a manageable number of representative scenarios covering a wide range of future developments.
Ozgur Yanmaz, Umut Asan
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source