Results 71 to 80 of about 124,244 (302)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Stability analysis of two stage stochastic mathematical programs with complementarity constraints via NLP-regularization [PDF]

This paper presents numerical approximation schemes for a two stage stochastic programming problem where the second stage problem has a general nonlinear complementarity constraint: first, the complementarity constraint is approximated by a parameterized
Xu, Huifu, Lin, Gui-Hua, Liu, Yongchao
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Current directions in hyper-programming [PDF]

, 2000
The traditional representation of a program is as a linear sequence of text. At some stage in the execution sequence the source text is checked for type correctness and its translated form is linked to values in the environment.
Graham N. C. Kirby, Cutts, Quintin I, Quintin I. Cutts, Farkas, Alex, Kirby, Graham N C, Robert McGettrick, Morrison, R, Alex Farkas, Kirby, G N C, Dearle, A, Connor, R C H, McGettrick, R, Evangelos Zirintsis, Connor, Richard C H, Dearle, Alan, Richard C. H. Connor, Ronald Morrison, Cutts, Q I, Farkas, A, Morrison, Ronald, Zirintsis, Evangelos, Alan Dearle, McGettrick, Robert   +22 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Municipal solid waste supply chain optimization for value-added product development under uncertainty

Waste Management Bulletin
Optimizing municipal solid waste (MSW) management through the production of valuable products and energy conversion is crucial to mitigate environmental damage and promote economic sustainability.
Muazzam Mukhtar, Muhammad Rizwan, Atta Ullah, Ali Elkamel, Salman Raza Naqvi, Muhammad Zaman   +5 more
doaj   +1 more source

Revisiting lagrange relaxation (LR) for processing large-scale mixed integer programming (MIP) problems [PDF]

, 2004
Lagrangean Relaxation has been successfully applied to process many well known instances of NP-hard Mixed Integer Programming problems. In this paper we present a Lagrangean Relaxation based generic solver for processing Mixed Integer Programming ...
Siamitros, C, Mitra, G, Poojari, CA
core  

A two-stage approach to the UCITS-constrained index-tracking problem [PDF]

, 2019
Undertakings for Collective Investments in Transferable Securities (UCITS) are investment funds that are regulated by the European Union. UCITS have become increasingly popular, resulting in a total corresponding amount of assets under management of € 8 ...
Trautmann, Norbert, Strub, Oliver
core   +1 more source