Results 111 to 120 of about 746,046 (294)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Global supply chains of high value low volume products [PDF]

open access: yes, 2007
Imperial Users ...
De Sousa, Rui Pedro Domingos Tavares   +1 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Stochastic utility-efficient programming of organic dairy farms [PDF]

open access: yes, 2005
Opportunities to make sequential decisions and adjust activities as a season progresses and more information becomes available characterise the farm management process.
G., Lien, O., Flaten
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

The effect of missing values using genetic programming on evolvable diagnosis [PDF]

open access: yes, 2002
Medical databases usually contain missing values due the policy of reducing stress and harm to the patient. In practice missing values has been a problem mainly due to the necessity to evaluate mathematical equations obtained by genetic programming ...
Kalganova, T, Werner, JC
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

MANAGING UNCERTAINTY IN AGRICULTURAL PRODUCTION: A TWO-STAGE STOCHASTIC PROGRAMMING APPROACH

open access: yes, 2023
Agriculture, a crucial contributor to Australia’s GDP, exports, and economy, involves inherent risk and uncertainty. Amidst these challenges, Australian farmers must craft optimal crop and livestock strategies to minimize risk whilst meeting their objectives.
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Use interactive multimedia to improve your programming course [PDF]

open access: yes, 2001
This paper reports first year students’ experiences with multimedia-based learning for programming and its influence on students obtained from two case studies at Napier and Brunel universities.
Cairncross, S, Choi, S, Kalganova, T
core  

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