Results 71 to 80 of about 741,553 (274)

A fully intuitionistic fuzzy multi-objective linear fractional fixed charge optimization model for sustainable transportation planning in the sugar-mill industry [PDF]

Archives of Control Sciences
Sustainability has recently grown to be a primary focus for transport planning and policies in both developing and developed nations. The paper focuses on the sustainability of a multiobjective linear fractional fixed charge transportation model that ...
Sakshi Dhruv, Ritu Arora, Shalini Arora, S.A. Edalatpanah   +3 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Theory and Applications of Robust Optimization [PDF]

, 2010
In this paper we survey the primary research, both theoretical and applied, in the area of Robust Optimization (RO). Our focus is on the computational attractiveness of RO approaches, as well as the modeling power and broad applicability of the ...
Banerjee O., Constantine Caramanis, d'Aspremont A., David B. Brown, Dimitris Bertsimas, Kim S.-J., Lanckriet G., Markowitz H., Oishi Y., Shivaswamy P., Xu H.   +10 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Approach for Optimizing 3D Highway Alignments Based on Two-stage Dynamic Programming

Journal of Software, 2013
Optimizing highway alignments is a very complex engineering problem. None of existing methods has totally solved the problem In this paper we build an optimization model for highway 3D alignment based on two-stage dynamic programming, in which the comprehensive cost and design constraints are embedded.
Wei Li, Hao Pu, Haifeng Zhao, Wei Liu
openaire   +1 more source

Two-stage optimisation of the multiphase production [PDF]

, 1999
Two approaches to the optimisation of the multiphase production process are presented in this paper. The first model - model I is a static one, using enterprise input/output modelling and linear programming simultaneously.
J. Artenjak, P. Tominac
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A two-stage stochastic integer programming approach

, 2005
This research has been partially support by the grant Grupo consolidado de alto rendimiento 9/UPV 00038.321-13631/2001 from UPV, the project MEC2001-0636 from the DGCIT, the Researchers’ Education grant program 2000 from Gobierno Vasco, and the grant GRUPOS79/04 from the Generalitat Valenciana, Spain.
Merino Maestre, María, Pérez Sainz de Rozas, Gloria, Escudero Bueno, Laureano F., Garín Martín, María Araceli   +3 more
openaire   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source