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Nature Reviews Disease Primers, 2017
Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease characterized by insulin deficiency due to pancreatic β-cell loss and leads to hyperglycaemia. Although the age of symptomatic onset is usually during childhood or adolescence, symptoms can sometimes develop much later.
Anastasia, Katsarou +8 more
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Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease characterized by insulin deficiency due to pancreatic β-cell loss and leads to hyperglycaemia. Although the age of symptomatic onset is usually during childhood or adolescence, symptoms can sometimes develop much later.
Anastasia, Katsarou +8 more
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Current Diabetes Reports, 2005
Predicting type 1 diabetes mellitus (T1DM) is a prerequisite for disease prevention. Prediction is currently performed on three levels, which include the genetic susceptibility for disease, the identification of preclinical T1DM by way of circulating islet autoantibodies, and the use of metabolic tests to stage preclinical disease into late or early ...
Peter, Achenbach +2 more
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Predicting type 1 diabetes mellitus (T1DM) is a prerequisite for disease prevention. Prediction is currently performed on three levels, which include the genetic susceptibility for disease, the identification of preclinical T1DM by way of circulating islet autoantibodies, and the use of metabolic tests to stage preclinical disease into late or early ...
Peter, Achenbach +2 more
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Evolving type 1 diabetes in distinguishing between type 1 and type 2 diabetes
BMJ, 2020Distinguishing between newly diagnosed type 1 or type 2 diabetes can be challenging.1 As a nation, we are becoming more obese, thus increasing predisposition to type 2 diabetes, and we are more often recognising type 1 diabetes in older adults.23 This can blur the lines between type 1 and type 2 diabetes. All relevant factors should be considered when
N E, Hill, N S, Oliver
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Journal of Diabetes and its Complications, 2001
The purpose of this article is to review the available pathophysiological and clinical studies of patients with idiopathic Type 1 diabetes. Idiopathic Type 1 diabetes is a common form of diabetes most commonly seen in obese African American individuals living in large urban areas.
A, Piñero-Piloña, P, Raskin
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The purpose of this article is to review the available pathophysiological and clinical studies of patients with idiopathic Type 1 diabetes. Idiopathic Type 1 diabetes is a common form of diabetes most commonly seen in obese African American individuals living in large urban areas.
A, Piñero-Piloña, P, Raskin
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FP essentials, 2021
Type 1 diabetes is defined as a state of hyperglycemia due to insulin deficiency caused by autoimmune pancreatic beta-cell destruction. The risk among individuals in the general population has been estimated at 0.5%. A family history of diabetes and a personal history of conditions associated with type 1 diabetes (ie, autoimmune diseases) increase the ...
Magdalena, Pasarica +2 more
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Type 1 diabetes is defined as a state of hyperglycemia due to insulin deficiency caused by autoimmune pancreatic beta-cell destruction. The risk among individuals in the general population has been estimated at 0.5%. A family history of diabetes and a personal history of conditions associated with type 1 diabetes (ie, autoimmune diseases) increase the ...
Magdalena, Pasarica +2 more
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2003
Diabetes is a complex metabolic disorder diagnosed on the basis of hyperglycemia. Diagnostic criteria for the disorder are periodically revised (1). Diabetes may be classified mainly into types 1 and 2 based on the etiology and severity of insulin deficiency (1).
Yogish C. Kudva +2 more
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Diabetes is a complex metabolic disorder diagnosed on the basis of hyperglycemia. Diagnostic criteria for the disorder are periodically revised (1). Diabetes may be classified mainly into types 1 and 2 based on the etiology and severity of insulin deficiency (1).
Yogish C. Kudva +2 more
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2009
Type 1 diabetes is a life long metabolic disorder that is characterized by absolute insulin deficiency resulting in hyperglycemia and lipolysis. Type 1 diabetes accounts for 5–10% of the total diabetes population, the majority of the other patients has type 2 diabetes. Insulin deficiency originates with autoimmune mediated β-cell destruction.
Edith W.M.T. ter Braak +1 more
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Type 1 diabetes is a life long metabolic disorder that is characterized by absolute insulin deficiency resulting in hyperglycemia and lipolysis. Type 1 diabetes accounts for 5–10% of the total diabetes population, the majority of the other patients has type 2 diabetes. Insulin deficiency originates with autoimmune mediated β-cell destruction.
Edith W.M.T. ter Braak +1 more
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Nature Immunology, 2001
Type 1 diabetes is preventable in animal models and predictable in humans. The increase in our knowledge of basic immunology has allowed the initiation of large-scale clinical efforts to prevent diabetes.
Kai W. Wucherpfennig +1 more
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Type 1 diabetes is preventable in animal models and predictable in humans. The increase in our knowledge of basic immunology has allowed the initiation of large-scale clinical efforts to prevent diabetes.
Kai W. Wucherpfennig +1 more
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2017
This chapter discusses the epidemiology, genetics, and pathophysiology of type 1 diabetes including insulinitis and β-cell destruction in the Eisenbarth model of pathogenesis. Complications of type 1 diabetes and pregnancy are reviewed, and diagnosis and management are discussed.
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This chapter discusses the epidemiology, genetics, and pathophysiology of type 1 diabetes including insulinitis and β-cell destruction in the Eisenbarth model of pathogenesis. Complications of type 1 diabetes and pregnancy are reviewed, and diagnosis and management are discussed.
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2016
Type 1 (insulin-dependent) diabetes occurs worldwide and can appear at any age. The genetic susceptibility is strongly associated with HLA-DQ and DR on chromosome 6, but genetic factors on other chromosomes such as the insulin gene on chromosome 11 and the cytotoxic T-lymphocyte antigen gene on chromosome 2 may modulate disease risk.
Åke Lernmark, Shehab Alshiekh
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Type 1 (insulin-dependent) diabetes occurs worldwide and can appear at any age. The genetic susceptibility is strongly associated with HLA-DQ and DR on chromosome 6, but genetic factors on other chromosomes such as the insulin gene on chromosome 11 and the cytotoxic T-lymphocyte antigen gene on chromosome 2 may modulate disease risk.
Åke Lernmark, Shehab Alshiekh
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