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Current Opinion in Genetics & Development, 2018
Type 1 diabetes is the most common autoimmune disorder in childhood, characterized by the development of autoimmunity through unknown environmental insults in genetically susceptible individuals. There are now over 50 regions of the genome that harbor type 1 diabetes susceptibility genes, with much of the genetic risk now well-defined in youth of ...
Catherine C .Robertson, Stephen S Rich
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Type 1 diabetes is the most common autoimmune disorder in childhood, characterized by the development of autoimmunity through unknown environmental insults in genetically susceptible individuals. There are now over 50 regions of the genome that harbor type 1 diabetes susceptibility genes, with much of the genetic risk now well-defined in youth of ...
Catherine C .Robertson, Stephen S Rich
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Nursing Clinics of North America, 2017
Comprehensive type 1 diabetes management requires understanding of the pathophysiology of disease and the ability to contrast this process with type 2 diabetes. Nurses are often the first contact with patients and must be aware of the advancements in detection, therapies, and signs of complications in these patients.
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Comprehensive type 1 diabetes management requires understanding of the pathophysiology of disease and the ability to contrast this process with type 2 diabetes. Nurses are often the first contact with patients and must be aware of the advancements in detection, therapies, and signs of complications in these patients.
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Best Practice & Research Clinical Endocrinology & Metabolism, 2001
Type 1 diabetes mellitus is a T-cell-mediated autoimmune disease characterized by the selective destruction of pancreatic beta cells. Susceptibility to the disease is determined by a combination of genetic and environmental factors. The genetic factors are termed 'susceptibility genes' as they modify the risk of diabetes but are neither necessary nor ...
M A, Kelly, C H, Mijovic, A H, Barnett
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Type 1 diabetes mellitus is a T-cell-mediated autoimmune disease characterized by the selective destruction of pancreatic beta cells. Susceptibility to the disease is determined by a combination of genetic and environmental factors. The genetic factors are termed 'susceptibility genes' as they modify the risk of diabetes but are neither necessary nor ...
M A, Kelly, C H, Mijovic, A H, Barnett
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Médecine et Santé Tropicales, 2018
Late diagnosis and lack of access to insulin contribute most to the mortality of people with type 1 diabetes. The presence of this chronic noncommunicable disease is not bound by borders or even continents. Without treatment, it is fatal, while with treatment and good control, it is possible to prevent acute complications (hyperglycemia and ...
C, De Beaufort, S, Besançon, N, Balde
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Late diagnosis and lack of access to insulin contribute most to the mortality of people with type 1 diabetes. The presence of this chronic noncommunicable disease is not bound by borders or even continents. Without treatment, it is fatal, while with treatment and good control, it is possible to prevent acute complications (hyperglycemia and ...
C, De Beaufort, S, Besançon, N, Balde
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The Foundation Years, 2002
Abstract Failure of the thyroid gland requires thyroid hormone replacement therapy, which is relatively easily adjusted to replicate the normal physiological state by monitoring plasma levels of thyroxine and/or thyroid-stimulating hormone. In contrast, failure of pancreatic b-cells requires insulin therapy, and optimal replacement requires monitoring,
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Abstract Failure of the thyroid gland requires thyroid hormone replacement therapy, which is relatively easily adjusted to replicate the normal physiological state by monitoring plasma levels of thyroxine and/or thyroid-stimulating hormone. In contrast, failure of pancreatic b-cells requires insulin therapy, and optimal replacement requires monitoring,
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The Evolution of Type 1 Diabetes
JAMA, 2013T YPE 1 DIABETES (T1D) OCCURS IN INDIVIDUALS WITH a genetic predisposition to the disease, predominantly from a human leukocyte antigen (HLA)related immunogenotype that accounts for approximately 60% of the genetic influence. In these individuals who are genetically at risk, an environmental trigger is thought to initiate an immune response targeting ...
Jay S, Skyler, Jay M, Sosenko
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Immunotherapy for type 1 diabetes
Journal of Endocrinological Investigation, 2017Although many approaches have been tested to overcome the insulin dependence caused by the pancreatic β-cells destruction observed in individuals affected by type 1 diabetes (T1D), medical research has largely failed to halt the onset or to reverse T1D.In this work, the state of the art of immunotherapy will be examined, and the most important ...
D. Frumento +5 more
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Nature Reviews Disease Primers, 2017
Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease characterized by insulin deficiency due to pancreatic β-cell loss and leads to hyperglycaemia. Although the age of symptomatic onset is usually during childhood or adolescence, symptoms can sometimes develop much later.
Anastasia, Katsarou +8 more
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Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease characterized by insulin deficiency due to pancreatic β-cell loss and leads to hyperglycaemia. Although the age of symptomatic onset is usually during childhood or adolescence, symptoms can sometimes develop much later.
Anastasia, Katsarou +8 more
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Medicine, 2002
Abstract Type 1 diabetes mellitus (T1DM) is a chronic disease characterized by hyperglycaemia secondary to inadequate production of insulin by the pancreas. This is the result of T cell-mediated autoimmune destruction of the insulin-producing β cells in the islets of Langerhans, and is associated with circulating autoantibodies to β cell antigens. The
Lambert, P, Bingley, PJ
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Abstract Type 1 diabetes mellitus (T1DM) is a chronic disease characterized by hyperglycaemia secondary to inadequate production of insulin by the pancreas. This is the result of T cell-mediated autoimmune destruction of the insulin-producing β cells in the islets of Langerhans, and is associated with circulating autoantibodies to β cell antigens. The
Lambert, P, Bingley, PJ
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New England Journal of Medicine, 2001
In this issue of the Journal, Martin et al.1 present a striking report of a boy with X-linked agammaglobulinemia in whom typical type 1 insulin-dependent diabetes mellitus developed at the age of 14 years. This report is of great interest because it shows that type 1 diabetes can develop in the complete absence of B cells and autoantibodies.
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In this issue of the Journal, Martin et al.1 present a striking report of a boy with X-linked agammaglobulinemia in whom typical type 1 insulin-dependent diabetes mellitus developed at the age of 14 years. This report is of great interest because it shows that type 1 diabetes can develop in the complete absence of B cells and autoantibodies.
openaire +2 more sources