Results 111 to 120 of about 1,627,676 (310)

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Roles of Bcl-3 in the pathogenesis of murine type 1 diabetes [PDF]

, 2010
OBJECTIVE: It has long been recognized that autoimmunity is often associated with immunodeficiency. The mechanism underlying this paradox is not well understood.
Ruaidhri J. Carmody, Shi-Jun Zheng, Scott Palmer, Palmer, S., Ruan, Q., Chen, Y.H., Carmody, R.J., Youhai H. Chen, Zheng, S.-J., Qingguo Ruan   +9 more
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Reperfusion‐Dependent Outcomes After Endovascular Thrombectomy Stratified by NIHSS‐ASPECTS Clinical‐Core Mismatch

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht, Lukas Meyer, Gabriel Broocks, Matthias Bechstein, Christian Thaler, Christian Heitkamp, Laurens Winkelmeier, Vincent Geest, Alexander Heitkamp, Maximilian Jungnitz, Gregor Peter, Luca Meucci, Tobias Faizy, Jawed Nawabi, Caspar Brekenfeld, Fabian Flottmann, Maximilian Schell, Alexandros Hadjilaou, Uta Hanning, Götz Thomalla, Jens Fiehler, Susanne Gellißen, Helge C. Kniep, for the German Stroke Registry Endovascular Treatment, (GSR‐ET) Alexander Nave, Anna Alegiani, Annerose Mengel, Arno Reich, Bernd Eckert, Charlotte Pietrock, Christian Nolte, Eberhard Siebert, Fabian Flottmann, Fee Keil, Franziska Dorn, Gabor Petzold, Götz Thomalla, Hanna Zimmermann, Jan Borggrefe, Jan Hendrik Schäfer, Jens Fiehler, Joachim Röther, Klaus Gröschel, Lars Kellert, Mario Abruscato, Maximilian Schell, Omid Nikoubashman, Peter Schellinger, Silke Wunderlich, Steffen Tiedt, Sven Thonke, Timo Uphaus, Tobias Boeckh‐Behrens, Ulrike Ernemann   +53 more
wiley   +1 more source

Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study [PDF]

, 2014
OBJECTIVE The long-term association between dietary protein and type 2 diabetes incidence is uncertain. We aimed to investigate the association between total, animal, and plant protein intake and the incidence of type 2 diabetes.
Tjonneland, Anne, Wurtz, Anne M. L., Daphne, L. van der A., Franks, Paul W., Molina, Esther, Zamora-Ros, Raul, Schulze, Matthias B., Spijkerman, Annemieke M.W., Beulens, Joline W. J., Kuhn, Tilman, Key, Timothy J., Palli, Domenico, Huerta, José Maria, Romieu, Isabelle, Riboli, Elio, Sánchez, Maria José, Tumino, Rosario, Wareham, Nicholas J., Halkjaer, Jytte, van Nielen, Monique, Sacerdote, Carlotta, Ardanaz, Eva, Lund University., Krogh, Vittorio, Panico, Salvatore, Balkau, Beverly, Nilsson, Peter,, Franks, Paul,, Forouhi, Nita G., Beulens, Joline W.J., Langenberg, Claudia, Clavel-Chapelon, Francoise, Menéndez, Virginia V.M., Feskens, Edith J.M., Rolandsson, Olov, Feskens, Edith J. M., Menendez, Virginia V. M., Overvad, Kim, Khaw, Kay Tee, Nilsson, Peter, Sanchez, Maria-Jose, Spijkerman, Annemieke M. W., Katzke, Verena, Amiano, Pilar, Franks, Paul, Maria Huerta, Jose, Sharp, Stephen J., Mensink, Marco, Rolandsson, Olov,, Boeing, Heiner, Sluijs, Ivonne, Fagherazzi, Guy, Würtz, Anne M.L., Van Der A, Daphne L.   +53 more
core   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Contemporary risk of hip fracture in type 1 and type 2 diabetes:a national registry study from Scotland [PDF]

, 2014
The purpose of this study was to compare contemporary risk of hip fracture in type 1 and type 2 diabetes with the nondiabetic population. Using a national diabetes database, we identified those with type 1 and type 2 diabetes who were aged 20 to 84 years
McKnight, John, Looker, Helen C., Leese, Graham P., Livingstone, Shona J., Wild, Sarah H., Ahmed, S. Faisal, Philip, Sam, Wild, Sarah H.; id_orcid, Hothersall, Eleanor J., Cleland, Steve, Lindsay, Robert S., Cleland, Steve., Pearson, Donald, Colhoun, Helen M.   +13 more
core   +1 more source

Advances and counterpoints in type 2 diabetes. What is ready for translation into real-world practice, ahead of the guidelines

BMC Medicine
This review seeks to address major gaps and delays between our rapidly evolving body of knowledge on type 2 diabetes and its translation into real-world practice.
Stanley S. Schwartz, Barbara E. Corkey, James R Gavin, Ralph A. DeFronzo, Mary E. Herman   +4 more
doaj   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Polymorphisms of the _ENPP1_ gene are not associated with type 2 diabetes or obesity in the Chinese Han population [PDF]

, 2008
*Objective:* Type 2 Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia and with a major feature of insulin resistance. Genetic association studies have suggested that _ENPP1_ might play a potential role in susceptibility to ...
Daizhan Zhou, Sheng Li, Yun Liu, He Xu, Lin He, Zuofeng Zhang, Zhuo Chen, Simin Liu, Lan Yu, Teng Zhao, Guoyin Feng, Di Zhang   +11 more
core   +1 more source