Results 141 to 150 of about 5,917,232 (403)

Integration of disease-specific single nucleotide polymorphisms, expression quantitative trait loci and coexpression networks reveal novel candidate genes for type 2 diabetes. [PDF]

, 2012
Aims/hypothesisWhile genome-wide association studies (GWASs) have been successful in identifying novel variants associated with various diseases, it has been much more difficult to determine the biological mechanisms underlying these associations ...
Butte, AJ, Chen, R, Corona, E, Kang, HP, Schadt, EE, Yang, X, Zhang, B   +6 more
core   +2 more sources

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Assessing the effectiveness of a clinic-based diabetes management program in a community setting [PDF]

, 2013
Diabetes in the United States occurs in approximately 8% of adults.[i] Diabetes, if not treated, can lead to many health problems such as blindness or loss of physical functioning, sometimes leading to amputation. However, Type 2 diabetes can be cured
Lupone, Justin
core   +1 more source

The potential for deprescribing in care home residents with Type 2 diabetes [PDF]

, 2016
Background: Type 2 diabetes is a common diagnosis in care home residents that is associated with potentially inappropriate prescribing and thus risk of additional suffering.
Andreassen, Lillan Mo, Desborough, James Antony, Houghton, Julie, Kjome, Reidun Lisbet Skeide, Sølvik, Una Ørvim   +4 more
core   +1 more source

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes.

New England Journal of Medicine, 2015
BACKGROUND Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease.
Jennifer B. Green, M. A. Bethel, P. Armstrong, J. Buse, S. Engel, Jyotsna Garg, R. Josse, K. Kaufman, J. Koglin, S. Korn, J. Lachin, Darren K Mcguire, M. Pencina, E. Standl, P. Stein, S. Suryawanshi, F. Van de Werf, E. Peterson, R. Holman   +18 more
semanticscholar   +1 more source

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

FEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang, Jiang Tan, Xueting He, Yuqin Chen, Guoping Qiu, Mei Yang   +5 more
wiley   +1 more source

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

Science, 2018
Microbial modulation of diabetes Short-chain fatty acids (SCFAs) are produced by various human gut microbes. SCFAs act as an energy source to the colonic epithelium and are also sensed by host signaling pathways that modulate appetite and inflammation ...
Liping Zhao, Feng Zhang, Xiaoying Ding, Guojun Wu, Y. Lam, Xuejiao Wang, Huaqing Fu, Xinhe Xue, Chunhua Lu, Jilin Ma, Lihua Yu, Chen-Si-Han Xu, Zhongying Ren, Ying Xu, Songmei Xu, Hong Shen, Xiuli Zhu, Yunshen Shi, Qingyun Shen, Wei-ping Dong, R. Liu, Yunxia Ling, Yue Zeng, Xingpeng Wang, Qianpeng Zhang, Jing Wang, Linghua Wang, Yanqiu Wu, B. Zeng, Hong Wei, Menghui Zhang, Yongde Peng, Chenhong Zhang   +32 more
semanticscholar   +1 more source

Association of SGLT2 Inhibitors With Cardiovascular and Kidney Outcomes in Patients With Type 2 Diabetes

JAMA cardiology, 2020
This meta-analysis uses data from patients with type 2 diabetes from 6 outcomes trials to investigate the association of sodium-glucose cotransporter 2 inhibitors with cardiovascular- and kidney disease–related outcomes.
D. McGuire, W. Shih, F. Cosentino, B. Charbonnel, D. Cherney, S. Dagogo-Jack, R. Pratley, Michelle Greenberg, Shuai Wang, S. Huyck, I. Gantz, S. Terra, Urszula Masiukiewicz, C. Cannon   +13 more
semanticscholar   +1 more source

Genetics of type 2 diabetes

Current Opinion in Genetics & Development, 2007
Identification and characterization of genetic variants that either cause or predispose to diabetes are a major focus of biomedical research. As of early 2007, the molecular basis of most forms of monogenic diabetes resulting from beta-cell dysfunction is known and, in particular, there has been recent success in delineating the genetic aetiology of ...
Mark I. McCarthy, Mark I. McCarthy, Katharine R. Owen   +2 more
openaire   +4 more sources

An enzyme‐linked immunosorbent assay (ELISA)‐based activity assay for AMP‐activated protein kinase (AMPK)

FEBS Open Bio, EarlyView.
Measuring AMP‐activated protein kinase (AMPK) activity in vitro is crucial for testing AMPK activators or inhibitors with therapeutic potential. Here, we report an enzyme‐linked immunosorbent assay (ELISA)‐based AMPK activity assay with simple steps and high sensitivity, which offers a simple, robust, and cost‐effective alternative to traditional ...
Trezze P. Nguyen, Shangze Lyu, Yang Liu
wiley   +1 more source