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Endocrine Practice, 2003
OBJECTIVES After participating in the CME activity, primary care physicians should be able to: 1. Know the clinical features of the insulin resistance syndrome 2. Understand the role of insulin resistance in the pathogenesis of type 2 diabetes 3. Be familiar with the agents used in the management of patients with type 2 diabetes 4.
Matthew C. Leinung +5 more
openaire +2 more sources
OBJECTIVES After participating in the CME activity, primary care physicians should be able to: 1. Know the clinical features of the insulin resistance syndrome 2. Understand the role of insulin resistance in the pathogenesis of type 2 diabetes 3. Be familiar with the agents used in the management of patients with type 2 diabetes 4.
Matthew C. Leinung +5 more
openaire +2 more sources
Seminars in Fetal and Neonatal Medicine, 2005
Type 2 diabetes is a growing concern, with the number of new cases increasing and occurring at a younger age due to obesity. Consequently the number of cases arising in women of child-bearing age is increasing, and the condition will be encountered more frequently in the antenatal clinic. Type 2 diabetes is often perceived as a benign form of diabetes,
openaire +2 more sources
Type 2 diabetes is a growing concern, with the number of new cases increasing and occurring at a younger age due to obesity. Consequently the number of cases arising in women of child-bearing age is increasing, and the condition will be encountered more frequently in the antenatal clinic. Type 2 diabetes is often perceived as a benign form of diabetes,
openaire +2 more sources
2016
Genetic and environmental factors as well as their interactions contribute to the pathogenesis of type 2 diabetes. Linkage analysis, candidate gene approaches, genome-wide association studies, and sequencing have been used in the identification of common, low-frequency and rare variants for type 2 diabetes.
Yaluri Alena +2 more
openaire +2 more sources
Genetic and environmental factors as well as their interactions contribute to the pathogenesis of type 2 diabetes. Linkage analysis, candidate gene approaches, genome-wide association studies, and sequencing have been used in the identification of common, low-frequency and rare variants for type 2 diabetes.
Yaluri Alena +2 more
openaire +2 more sources
Nature Reviews Disease Primers, 2015
Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular complications (including retinopathy, nephropathy and neuropathy) and macrovascular complications (such as cardiovascular comorbidities), owing to hyperglycaemia and individual ...
DeFronzo, Ralph A +12 more
openaire +3 more sources
Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular complications (including retinopathy, nephropathy and neuropathy) and macrovascular complications (such as cardiovascular comorbidities), owing to hyperglycaemia and individual ...
DeFronzo, Ralph A +12 more
openaire +3 more sources
2011
The evolving concept of how nutrient excess and inflammation modulate metabolism provides new opportunities for strategies to correct the detrimental health consequences of obesity. In this review, we focus on the complex interplay among lipid overload, immune response, proinflammatory pathways and organelle dysfunction through which excess adiposity ...
Christina, Schwanstecher +1 more
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The evolving concept of how nutrient excess and inflammation modulate metabolism provides new opportunities for strategies to correct the detrimental health consequences of obesity. In this review, we focus on the complex interplay among lipid overload, immune response, proinflammatory pathways and organelle dysfunction through which excess adiposity ...
Christina, Schwanstecher +1 more
openaire +2 more sources
Epigenetics and Type 2 Diabetes
2011Type 2 diabetes mellitus (T2D) is a chronic multifactorial disease characterized by hyperglycemia, a result of impaired pancreatic beta cell function and insulin resistance by liver and peripheral target tissues, e.g., skeletal muscle and adipose tissue.
Ling, Charlotte +2 more
openaire +4 more sources
2012
This chapter deals with type 2 diabetes in vivo models and techniques suitable for testing new anti-diabetic compounds. In particular, the testing of TRP antagonist for beneficial effects against type 2 diabetes is considered. There are many choices of both in vitro techniques and in vivo models and in principle they can be combined in various ways ...
openaire +2 more sources
This chapter deals with type 2 diabetes in vivo models and techniques suitable for testing new anti-diabetic compounds. In particular, the testing of TRP antagonist for beneficial effects against type 2 diabetes is considered. There are many choices of both in vitro techniques and in vivo models and in principle they can be combined in various ways ...
openaire +2 more sources