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The Lancet, 2017
415 million people live with diabetes worldwide, and an estimated 193 million people have undiagnosed diabetes. Type 2 diabetes accounts for more than 90% of patients with diabetes and leads to microvascular and macrovascular complications that cause profound psychological and physical distress to both patients and carers and put a huge burden on ...
Sudesna, Chatterjee +2 more
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415 million people live with diabetes worldwide, and an estimated 193 million people have undiagnosed diabetes. Type 2 diabetes accounts for more than 90% of patients with diabetes and leads to microvascular and macrovascular complications that cause profound psychological and physical distress to both patients and carers and put a huge burden on ...
Sudesna, Chatterjee +2 more
openaire +2 more sources
Annals of Internal Medicine, 2010
This issue provides a clinical overview of type 2 diabetes focusing on prevention, diagnosis, treatment, practice improvement, and patient information. Readers can complete the accompanying CME quiz for 1.5 credits. Only ACP members and individual subscribers can access the electronic features of In the Clinic.
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This issue provides a clinical overview of type 2 diabetes focusing on prevention, diagnosis, treatment, practice improvement, and patient information. Readers can complete the accompanying CME quiz for 1.5 credits. Only ACP members and individual subscribers can access the electronic features of In the Clinic.
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Diabetes, Obesity and Metabolism, 2008
Islets of patients with type 2 diabetes have the feature of an inflammatory process reflected by the presence of cytokines, immune cells, β‐cell apoptosis, amyloid deposits and fibrosis. Indeed, β‐cells from patients with type 2 diabetes display inflammatory markers, including increased interleukin (IL)‐1β expression.
Böni-Schnetzler, M +3 more
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Islets of patients with type 2 diabetes have the feature of an inflammatory process reflected by the presence of cytokines, immune cells, β‐cell apoptosis, amyloid deposits and fibrosis. Indeed, β‐cells from patients with type 2 diabetes display inflammatory markers, including increased interleukin (IL)‐1β expression.
Böni-Schnetzler, M +3 more
openaire +4 more sources
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Science, 2004Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show that obesity causes endoplasmic reticulum (ER) stress.
Umut Özcan +9 more
semanticscholar +1 more source
Genetics of Type 2 Diabetes [PDF]
, 2015 The promise of high-throughput genomics has started to deliver novel insights in the genetic etiology of type 2 diabetes and its related traits. In particular, genome-wide association studies have revealed new biological underpinnings to metabolic traits, with particular focus being on the strongest loci TCF7L2 and FTO.
Struan F.A. Grant, Struan F.A. Grant
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Annals of the New York Academy of Sciences, 2004
Abstract:Carnitine, the l‐β‐hydroxy‐γ‐N‐trimethylaminobutyric acid, is synthesized primarily in the liver and kidneys from lysine and methionine. Carnitine covers an important role in lipid metabolism, acting as an obligatory cofactor for β‐oxidation of fatty acids by facilitating the transport of long‐chain fatty acids across the mitochondrial ...
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Abstract:Carnitine, the l‐β‐hydroxy‐γ‐N‐trimethylaminobutyric acid, is synthesized primarily in the liver and kidneys from lysine and methionine. Carnitine covers an important role in lipid metabolism, acting as an obligatory cofactor for β‐oxidation of fatty acids by facilitating the transport of long‐chain fatty acids across the mitochondrial ...
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Pathogenesis of Type 2 Diabetes
Endocrine Research, 2007An enormous amount of research has been dedicated to unraveling the pathophysiology of type 2 diabetes mellitus over the last 30 years.
Barry J. Goldstein +2 more
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Type 2 Diabetes and Bacteremia
Annals of Nutrition and Metabolism, 2017Background: A high proportion of type 2 diabetes cases are associated with host genetic and environmental factors. During the past decade, microorganisms that inhabit the gut have emerged as contributors to the pathogenesis of obesity and type 2 diabetes.
Akio Kanazawa +2 more
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Biochemistry and Cell Biology, 2015
Since the 1990s, concerns about a global obesity epidemic have flourished. These concerns regarding obesity are expressed in popular culture and scientific literature and emphasize both weight and weight loss when defining health and well-being. As a result scholars are now calling attention to a “shadow epidemic” of weight stigma that is shown to ...
Caitlin O'Reilly, Erin Cameron
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Since the 1990s, concerns about a global obesity epidemic have flourished. These concerns regarding obesity are expressed in popular culture and scientific literature and emphasize both weight and weight loss when defining health and well-being. As a result scholars are now calling attention to a “shadow epidemic” of weight stigma that is shown to ...
Caitlin O'Reilly, Erin Cameron
openaire +3 more sources
The Nurse Practitioner, 2013
Ms. P is a 50-year-old, Black female diagnosed with type 2 diabetes after presenting to her primary care provider with polyuria, polydipsia, and blurry vision. She had a fasting blood glucose (BG) level of 204 mg/dL and a hemoglobin A1c (HbA1C) level of 7.8%. At this visit, Ms.
Bridget Everhart, Stacey Seggelke
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Ms. P is a 50-year-old, Black female diagnosed with type 2 diabetes after presenting to her primary care provider with polyuria, polydipsia, and blurry vision. She had a fasting blood glucose (BG) level of 204 mg/dL and a hemoglobin A1c (HbA1C) level of 7.8%. At this visit, Ms.
Bridget Everhart, Stacey Seggelke
openaire +2 more sources