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Acatalasemia and type 2 diabetes mellitus
Orvosi Hetilap, 2015The catalase enzyme decomposes the toxic concentrations of hydrogen peroxide into oxygen and water. Hydrogen peroxide is a highly reactive small molecule and its excessive concentration may cause significant damages to proteins, deoxyribonucleic acid, ribonucleic acid and lipids. Acatalasemia refers to inherited deficiency of the catalase enzyme.
László, Góth +2 more
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Type 2 Diabetes Mellitus in Youth
The Journal of School Nursing, 2003In the United States, the incidence of type 2 diabetes mellitus (DM) in children and adolescents has been increasing at an alarming rate. Early recognition and intervention can delay the onset of type 2 DM and prevent the long-term complications. School nurses have an essential role in implementing the American Diabetes Association (ADA) recommended ...
Jill L, Quarry-Horn +2 more
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Liraglutide for type 2 diabetes mellitus
Expert Opinion on Biological Therapy, 2011Prevalence of type 2 diabetes mellitus (T2DM) is increasing. Management of this condition and minimizing the cardiovascular risks associated with it poses a significant burden on healthcare resources across the world. Currently available therapeutic agents are effective in glycemic management; however, the majority of these are associated with ...
Kela, R, Khunti, K, Davies, MJ
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The Prevention of Type 2 Diabetes Mellitus
Endocrinology and Metabolism Clinics of North America, 2005With a worldwide pandemic of type 2 diabetes upon us, it is imperative that effective and practical preventive strategies be developed for this disease which, once established, carries with it excess morbidity and mortality. This article reviews recently published data on the prevention of type 2 diabetes and compares the demonstrated effectiveness of ...
Silvio E, Inzucchi, Robert S, Sherwin
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Type 2 Diabetes Mellitus in Children
Endocrine Practice, 1998To provide an overview of type 2 diabetes in children and discuss short-term and long-term management strategies.We review the distinction among various types of diabetes mellitus as they apply to children. In addition, we discuss determining the precise diagnosis between the two major variants--type 1 and type 2 diabetes--and clinical management of ...
J H, Pohl, J A, Greer, K S, Hasan
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Dyslipidemia in type 2 diabetes mellitus
Current Diabetes Reports, 2007Cardiovascular disease is a significant cause of morbidity and mortality in patients with diabetes mellitus (DM). DM is now recognized as a risk equivalent for coronary heart disease. The lipid profile in patients with type 2 DM is characterized by elevated triglycerides, low levels of high-density lipoprotein cholesterol, and small dense low-density ...
Ramprasad, Gadi, Frederick F, Samaha
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Exercise for type 2 diabetes mellitus
Cochrane Database of Systematic Reviews, 2006Exercise is generally recommended for people with type 2 diabetes mellitus. However, some studies evaluate an exercise intervention including diet or behaviour modification or both, and the effects of diet and exercise are not differentiated. Some exercise studies involve low participant numbers, lacking power to show significant differences which may ...
Thomas, Diana +2 more
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Dyslipidemia in type 2 diabetes mellitus
Nature Reviews Endocrinology, 2009Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. The characteristic features of diabetic dyslipidemia are a high plasma triglyceride concentration, low HDL cholesterol concentration and increased concentration of small dense LDL-cholesterol particles.
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Pathogenesis of type 2 diabetes mellitus
Experimental and Clinical Endocrinology & Diabetes, 2001Type 2 diabetes mellitus is a heterogeneous disorder with genetic and acquired components. It is primarily due to impaired insulin secretion in that individuals with genetically impaired beta cell function cannot increase their insulin release sufficiently to compensate for insulin resistance.
J, Dostou, J, Gerich
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Lixisenatide for type 2 diabetes mellitus
Expert Opinion on Investigational Drugs, 2011Type 2 diabetes mellitus (T2DM) is an increasing health problem worldwide. Glucagon-like peptide-1 (GLP-1) receptor agonists are an expanding drug class that target several of the pathophysiological traits of T2DM. Lixisenatide is a GLP-1 receptor agonist in development for once-daily treatment of T2DM.Pharmacological, preclinical and clinical evidence
Christensen, Mikkel +3 more
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