Results 121 to 130 of about 97,348,975 (279)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

NPY Levels In Type 1 Diabetic Men of Different Duration. [PDF]

, 2011
Background: The aim of the present study was to evaluate whether the different duration of type 1 diabetes mellitus influences basal NPY secretion. Design: The NPY concentrations were measured in sixty-eight men with insulin-dependent diabetes mellitus ...
Lavinia Volpi, Anna Araldi, Maria Grazia Magotti, Paolo Chiodera, Riccardo Volpi, Luigi Capretti, Claudio Giumelli, Vittorio Coiro, Simona Cataldo, Teore Ferri, Roberta Minelli   +10 more
core  

Characterization of the Bacillus subtilis ESX-­Type Protein Secretion System

, 2018
Esat-6 Protein Secretion Systems are required for the virulence of several human pathogens, most notably Mycobacterium tuberculosis and Staphylococcus aureus.
Huppert, Laura Ann
core   +4 more sources

Structure of the VipA/B Type VI Secretion Complex Suggests a Contraction-State-Specific Recycling Mechanism

Cell Reports, 2014
The bacterial type VI secretion system is a multicomponent molecular machine directed against eukaryotic host cells and competing bacteria. An intracellular contractile tubular structure that bears functional homology with bacteriophage tails is pivotal ...
Sebastian Kube, Nicole Kapitein, Tomasz Zimniak, Franz Herzog, Axel Mogk, Petra Wendler   +5 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Genome-wide Investigation of Vibrio parahaemolyticus Type III Secretion System-1 Regulation and Chitin Metabolism

, 2022
Vibrio parahaemolyticus is the leading cause of seafood-borne gastroenteritis in humans following the consumption of contaminated seafood, and is a consequential organism for aquaculture and human health.
Getz, Landon John
core  

Faculty Opinions recommendation of Type 6 secretion system-mediated immunity to type 4 secretion system-mediated gene transfer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2013
Christoph Dehio, Arto Pulliainen
openaire   +3 more sources

Comparative Phenotypic and Transcriptomic Analysis Reveals Distinct Yet Partially Convergent Mechanisms of Daphnetin and 6-Methylcoumarin Against Eucalyptus-Derived Ralstonia pseudosolanacearum

Microorganisms
Eucalyptus bacterial wilt in China, caused predominantly by Ralstonia pseudosolanacearum, severely threatens Eucalyptus plantation management in China and demands plant-derived alternatives to conventional bactericides.
Han Xue, Ning Jiang, Yong Li
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Shutting Down Shigella Secretion: Characterizing Small Molecule Type Three Secretion System ATPase Inhibitors

, 2018
Spa47 inhibition data from "Shutting Down Shigella Secretion: Characterizing Small Molecule Type Three Secretion System ATPase Inhibitors".
Case, Heather, Case, Heather B., Case, Heather (4974191), Dickenson, Nicholas (5826329), Dickenson, Nicholas E, Dickenson, Nicholas   +5 more
core   +1 more source