Results 191 to 200 of about 139,845,986 (286)

Book of decorative materials

, 1913
American Type Founders Company
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Serial CT Imaging in a Male Child at Different Ages Demonstrating the Three Types of External Occipital Protuberance. [PDF]

Case Rep Orthop
Sun KM, Sun XF.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Longitudinal Single-Cell RNA Sequencing Reveals Evolution of Microstates and Macrostates in Chronic Myeloid Leukemia. [PDF]

Cancer Res
Frankhouser DE, Zhao D, Fu YH, Dey A, Chen Z, Irizarry J, Rangel Ambriz J, Kanesa Ybarra T, Branciamore S, O'Meally D, Sathianathen RS, Trent JM, Forman SJ, MacLean AL, Kuo YH, Sakamoto KM, Zhang B, Rockne RC, Marcucci G.   +18 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Structurally reorganized Wmk lineage with distinct genomic context and restricted distribution in Wolbachia. [PDF]

G3 (Bethesda)
Sahoo RK.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A cell type transcriptome atlas for human pituitary, adrenal, thyroid and minor salivary glands. [PDF]

BMC Genomics
Dusart P, Struck E, Zwahlen M, von Feilitzen K, Pontén F, Lindskog C, Odeberg J, Uhlén M, Butler LM.   +8 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Enhancing cell type deconvolution in spatial transcriptomics through incorporating multiple reference panels. [PDF]

PLoS Genet
Zhao P, Colacino JA, Ma Y, Zhou X.
europepmc   +1 more source