Results 51 to 60 of about 47,460 (264)

A New Morphological Variant of Acute Aortic Dissection, Non-A-Non-B Type: Choosing Treatment Strategy

Український журнал серцево-судинної хірургії, 2020
Treatment of acute aortic dissection is determined by the Stanford classification which classifies all cases as type A requiring emergency surgery, and type B managed with antihypertensive therapy, and, more recently, endovascular aneurysm repair.
L. Kulyk, D. Beshley, S. Lishchenko, V. Petsentii, A. Schnaidruk, S. Vyshynska   +5 more
doaj   +1 more source

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source

Indication of endovascular treatment of type B aortic dissection - Literature review

Brazilian Journal of Cardiovascular Surgery, 2014
Aortic dissection is a cardiovascular event of high mortality if not early diagnosed and properly treated. In Stanford type A aortic dissection, there is the involvement of the ascending aorta, whereas in type B the ascending aorta is not affected.
João Jackson Duarte, José Carlos Dorsa Vieira Pontes, Ricardo Adala Benfatti, Adriana Lugo Ferrachini, Walter Kegham Karakhanian, Álvaro Razuk Filho   +5 more
doaj   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Interrupted Aortic Arch Complicated with Type A Aortic Dissection in a Young Adult

Heart Views
Interrupted aortic arch (IAA) is a congenital anomaly characterized by a discontinuity between the ascending and descending aorta. We present a 27-year-old male patient who had presented with Stanford Type A aortic dissection and was subsequently found ...
Ashish Dua, Arun Sharma, Rupesh Kumar, Manphool Singhal   +3 more
doaj   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

The relationship of sex and aortic diameter at the time of acute type A aortic dissectionCentral MessagePerspective

JTCVS Open
Objective: Evaluate sex differences in patients undergoing repair of acute type A aortic dissection (ATAAD). Methods: Sex-stratified, single-center cohort study of patients undergoing ATAAD repair from 1997 to 2022.
Lamia Harik, MD, Mario Gaudino, MD, PhD, Mohammed Rahouma, MD, Arnaldo Dimagli, MD, Roberto Perezgrovas-Olaria, MD, Kevin R. An, MD, Talal Alzghari, MD, Giovanni Soletti, Jr., MD, Jordan Leith, BS, Gianmarco Cancelli, MD, Charles Mack, MD, Leonard N. Girardi, MD, Christopher Lau, MD   +12 more
doaj   +1 more source

Brain strokes related to aortic aneurysma – the analysis of three cases

Open Medicine, 2017
Brain stroke connected with aortic blood flow disturbances is a rare disease and its incidence is difficult to assume. Nevertheless, 10-50% of patients with aortic dissection may not experience any pain.
Pastuszak Żanna, Stępień Adam, Kordowska Joanna, Rolewska Agnieszka, Galbarczyk Dariusz   +4 more
doaj   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source