Results 241 to 250 of about 14,138,795 (349)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

CytoSpatio: Learning cell type spatial relationships using multirange, multitype point process models. [PDF]

PLoS Comput Biol
Chen H, Zhang Y, Murphy RF.
europepmc   +1 more source

Functionally diverse type V CRISPR-Cas systems

Science, 2019
Winston X. Yan, Pratyusha Hunnewell, Lauren E. Alfonse, J. Carte, Elise Keston-Smith, Shanmugapriya Sothiselvam, Anthony J. Garrity, S. Chong, K. Makarova, E. Koonin, David R. Cheng, David A. Scott   +11 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A mixture of attention experts-embedded flow-based generative model to create synthetic cells in single-cell RNA-Seq datasets. [PDF]

PLoS Comput Biol
Turgut Ögme SS, Aydin N, Kurt Z.
europepmc   +1 more source

The cell biology of lignification in higher plants.

Annals of Botany, 2015
J. Barros, H. Serk, I. Granlund, E. Pesquet   +3 more
semanticscholar   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Snapshot of Defense Systems in Multidrug Resistant <i>Klebsiella pneumoniae</i>. [PDF]

MicroPubl Biol
Senbadejo TY, Ntiamoah Osei S, Isawumi A.   +2 more
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Behavioral investigation of reactive and neoplastic lymphocytes in human lymph nodes in 4D. [PDF]

PLoS One
Theil DE, Bütow C, Scharf S, Schäfer H, Hartmann S, Hansmann ML, Wurzel P.   +6 more
europepmc   +1 more source