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The structural and molecular biology of type IV galactosemia
Biochimie, 2021Type IV galactosemia is a recently discovered inherited metabolic disease. It is caused by mutations in the GALM gene which result in reduced activity of the enzyme galactose mutarotase. This enzyme catalyses the interconversion of the α- and β-anomers of d-galactose and some other monosaccharides.
Samantha Banford, David J. Timson
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Structural Biology of Bacterial Type IV Secretion Systems
Annual Review of Biochemistry, 2015Type IV secretion systems (T4SSs) are large multisubunit translocons, found in both gram-negative and gram-positive bacteria and in some archaea. These systems transport a diverse array of substrates from DNA and protein–DNA complexes to proteins, and play fundamental roles in both bacterial pathogenesis and bacterial adaptation to the cellular milieu
Vidya, Chandran Darbari +1 more
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The Biology of Mediterranean-Type Ecosystems
2018The world’s mediterranean-type climate regions (including areas within the Mediterranean, South Africa, Australia, California, and Chile) have long been of interest to biologists by virtue of their extraordinary biodiversity and the appearance of evolutionary convergence between these disparate regions.
Karen J. Esler +2 more
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Molecular biology and pathology of type VII collagen*
Experimental Dermatology, 1992Abstract Type VII collagen is a genetically distinct member of the collagen family of proteins. Type VII collagen has been shown to be the major component of anchoring fibrils, attachment complexes which secure the cutaneous basement membrance of the skin to the underlying dermis. Understanding of the structure of type VII collagen has been advanced by
J, Uitto +2 more
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The Journal of Cardiovascular Nursing, 2003
Type 2 diabetes mellitus (DM), characterized by insulin resistance and a beta-cell secretory defect, appears to result from a number of gene and environmental interactions. There are marked differences in the phenotypic expression of type 2 DM with individuals exhibiting varying levels of insulin resistance and impairments in insulin secretion.
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Type 2 diabetes mellitus (DM), characterized by insulin resistance and a beta-cell secretory defect, appears to result from a number of gene and environmental interactions. There are marked differences in the phenotypic expression of type 2 DM with individuals exhibiting varying levels of insulin resistance and impairments in insulin secretion.
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Molecular biology of the human immunodeficiency virus type 1
The FASEB Journal, 1991The immunodeficiency virus type 1 is a complex retrovirus. In addition to genes that specify the proteins of the virus particle and the replicative enzymes common to all retroviruses, HIV‐1 specifies at least six additional proteins that regulate the virus life cycle. Two of these regulatory genes, tat
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HLA Typing From Serology to Molecular Biology
1997During the last few years Histocompatibility Laboratories have started to use DNA techniques. There are many benefits to using such techniques. There is no need for antisera, which are becoming very difficult to obtain as many laboratories have stopped screening for HLA reagents and few laboratories have the technology to produce specific HLA ...
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Structural and functional diversity of type IV secretion systems
Nature Reviews Microbiology, 2023Tiago R D Costa +2 more
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Type VII secretion systems: structure, functions and transport models
Nature Reviews Microbiology, 2021Angel Rivera-Calzada +2 more
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Cellular Biology and Pathology of Type II Pneumocytes
International Archives of Allergy and Immunology, 1985J, Chrétien +4 more
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