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TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach+8 more
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Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner+6 more
wiley +1 more source
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul+11 more
wiley +1 more source
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The structural and molecular biology of type IV galactosemia
Biochimie, 2021Type IV galactosemia is a recently discovered inherited metabolic disease. It is caused by mutations in the GALM gene which result in reduced activity of the enzyme galactose mutarotase. This enzyme catalyses the interconversion of the α- and β-anomers of d-galactose and some other monosaccharides.
Samantha Banford, David J. Timson
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Biology of T memory type 1 cells
Immunological Reviews, 2001Summary: Engagement of inhibitory natural killer (NK) cell receptors for MHC class I molecules (NKR) can impair NK‐cell activation programs. Inhibitory NKR thus confer to NK cells the capacity to discriminate between MHC class I+ and MHC class I− target cells, and are therefore involved in the control of NK‐cell tolerance to self, as well as in the ...
Eric Vivier+4 more
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Conservation Biology and Four Types of Advocacy
Conservation Biology, 2007The advocacy debate in ecology and conservation goes back a long way. In the early part of the twentieth century some ecologists were actively pursuing nature conservation, but others eschewed this kind of activism. When the Ecological Society of America (ESA) formed in 1915, a divide already existed regarding the mission of the society and the role of
Peter F. Brussard, John C. Tull
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Molecular biology for platelet alloantigen typing
Transfusion Medicine, 1992SUMMARY. Hitherto, full investigation of patients with alloimmunization to platelet‐specific antigens has been difficult due to the limited availability of both typing reagents and panels of typed platelets. Following recent advances in the understanding of the molecular and genetic basis of platelet alloantigens, it is now possible to genotype ...
Lorna M. Williamson+5 more
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Molecular Biology of T-Type Calcium Channels
CNS & Neurological Disorders - Drug Targets, 2006This review summarizes recent progress on the molecular biology of low voltage-gated, T-type, calcium channels. The genes encoding these channels were identified by molecular cloning of cDNAs that were similar in sequence to the alpha1 subunit of high voltage-activated Ca2+ channels.
Edward Perez-Reyes, Philippe Lory
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