Results 261 to 270 of about 16,440,357 (384)

Lumpy skin disease virus protein LSDV122 impairs IFN-I receptor complex formation to evade host innate immunity. [PDF]

PLoS Pathog
Sun MY, Cao LB, Wan QL, Li ZZ, Du JZ, Shu HB, Yang YL.   +6 more
europepmc   +1 more source

Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

Anna Morra, Maria Escala-Garcia, J. Beesley, Renske Keeman, Sander Canisius, Thomas U. Ahearn, I.L. Andrulis, H. Anton-Culver, Volker Arndt, Paul L. Auer, Annelie Augustinsson, Laura E. Beane Freeman, Heiko Becher, M.W. Beckmann, Sabine Behrens, Stig E. Bojesen, M. Bolla, Hermann Brenner, T. Brüning, SS Buys, Bette J. Caan, Daniele Campa, Federico Canzian, Jose E. Castelao, Jenny Chang‐Claude, S.J. Chanock, Ting Cheng, Christine L. Clarke, NBCS Collaborators, Sarah V. Colonna, F.J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, M.B. Daly, Joe Dennis, Thilo Dörk, Laure Dossus, A.M. Dunning, Miriam Dwek, Diana Eccles, Arif B. Ekici, A. Heather Eliassen, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Henrik Flyger, Lin Fritschi, Manuela Gago-Domínguez, José Á. García-Sáenz, Graham G. Giles, Mervi Grip, Pascal Guénel, Melanie Gündert, Eric Hahnen, C.A. Haiman, Niclas Håkansson, Per Hall, U. Hamann, Steven N. Hart, Jaana M. Hartikainen, Alain Hartmann, Wei He, Maartje J. Hooning, Reiner Hoppe, JL Hopper, Anthony Howell, David J. Hunter, ABCTB Investigators, kConFab Investigators, Agnes Jager, Anna Jakubowska, Wolfgang Janni, Esther M. John, Audrey Jung, R. Kaaks, Machteld Keupers, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Allison W. Kurian, J. Lacey, Diether Lambrechts, L. Le Marchand, A. Lindblom, Martha S. Linet, Robert Luben, Jan Lubiński, Michael Lush, Arto Mannermaa, Masood Manoochehri, Sara Margolin, J.W.M. Martens, Marı́a Elena Martı́nez, D. Mavroudis, Kyriaki Michailidou, Roger L. Milne, Anna Marie Mulligan, T.A. Muranen   +99 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

DDGWizard: Integration of feature calculation resources for analysis and prediction of changes in protein thermostability upon point mutations. [PDF]

PLoS Comput Biol
Wang M, Jumah K, Shao Q, Kamieniecka K, Liu Y, Poterlowicz K.   +5 more
europepmc   +1 more source

Functionally diverse type V CRISPR-Cas systems

Science, 2019
Winston X. Yan, Pratyusha Hunnewell, Lauren E. Alfonse, J. Carte, Elise Keston-Smith, Shanmugapriya Sothiselvam, Anthony J. Garrity, S. Chong, K. Makarova, E. Koonin, David R. Cheng, David A. Scott   +11 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

CeSTAAN: An atlas of <i>C. elegans</i> adult neurons for fast queries of single-nucleus RNA sequencing data. [PDF]

MicroPubl Biol
St Ange J, Langmack H, Murphy CT.
europepmc   +1 more source

What Is a Plant Cell Type in the Age of Single-Cell Biology? It's Complicated

Byron Rusnak, Frances K. Clark, Batthula Vijaya Lakshmi Vadde, Adrienne Roeder   +3 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Response to Comment on Samovski et al. Effect of Marked Weight Loss on Adipose Tissue Biology in People With Obesity and Type 2 Diabetes. Diabetes Care 2025;48:1342-1351. [PDF]

Diabetes Care
Samovski D, Smith GI, Palacios H, Pietka T, Fuchs A, Patti GJ, Nawaz A, Kahn CR, Klein S.   +8 more
europepmc   +1 more source