Results 41 to 50 of about 16,440,357 (384)

Structure and Biology of Type VIII Collagen.

Trends in Glycoscience and Glycotechnology, 1992
VIII型コラーゲンは、ウシ大動脈内皮細胞の培養系における生合成産物として最初に報告されたので、従来は内皮細胞コラーゲン (EC) と呼ばれていた。このタンパク質は現在、トリおよび哺乳類のケラチノサイト、線維芽細胞、星状細胞腫や他の腫瘍細胞、さらに様々な大きさの血管に由来する内皮細胞などによって分泌されることが知られている。生体内ではVIII型コラーゲンの分布は限られており、例えば髄膜、骨膜、軟骨膜、角膜のデスメ膜などの細胞外マトリックスに存在する。また大小血管の内皮下層や内皮細胞の発芽培養系で形成される毛細血管様構造にも存在する。タンパク質のアミノ酸配列と核酸塩基配列から、VIII型コラーゲンはα1 (VIII) およびα2 (VIII ...
Iruela-Arispe, M Luisa, Chun, Lawrence E, Sage, E Helene   +2 more
openaire   +4 more sources

Molecular biology for hpv typing in focal epithelial hyperplasia [PDF]

Turkish Journal of Pathology, 2015
Parichehr Ghalayani and colleagues (Volume 31, Number 1, Pages:060-063) report three interesting cases of focal epithelial hyperplasia (FEH) diagnosed through clinical and microscopic analysis (1). We would like to emphasize that, although the age and ethnicity of the patient may support the clinical suspicion of FEH, the histopathological features of ...
GP. Bombeccari, G. Guzzi, F. Pallotti, F. Spadari, AB.Gianni   +4 more
openaire   +3 more sources

Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host [PDF]

, 2013
Schmallenberg virus (SBV) is an emerging orthobunyavirus of ruminants associated with outbreaks of congenital malformations in aborted and stillborn animals.
A Bridgen, A Bridgen, A Kohl, AC Lowen, AJ Della-Porta, Alain Kohl, Andrew Shaw, Anna Janowicz, AR Elbers, B Hoffmann, B Xu, CA Evans, Catherine Lamm, Claudio Murgia, CM Southam, CT Walter, D Thomas, DH Cybinski, Esther Schnettler, Eva McGregor, F Arnaud, Friedemann Weber, G Barry, G Blakqori, G Blakqori, G Neumann, Gerald Barry, Ilaria M. Piras, JI Gillespie, JL Farmer, K Kupferschmidt, K Peperkamp, K Terasaki, K Wernike, KE Jones, Kerstin Hahn, KV Goller, LD Rasmussen, M Beer, M Bouloy, M Caporale, M Dominguez, M Palmarini, M Ratinier, M Spiegel, M Varela, Mandy Glass, Marco Caporale, Mariana Varela, Martin Beer, Massimo Palmarini, Melanie McFarlane, MJ Killip, MM Garigliany, MM Garigliany, NR Saunders, OR Causey, P Vialat, PJ Hotez, PT Leisnham, R Muller, RS Azevedo, S Shimshony, SE Randolph, T Ikegami, T Yanase, UJ Buchholz, V Herder, Vanessa Herder, VH Leonard, Wolfgang Baumgärtner, X Shi, Y Ogawa, YK Liao   +73 more
core   +3 more sources

Activation of macrophages by extracellular vesicles derived from Babesia-infected red blood cells

Infection and Immunity
Babesia microti is the primary cause of human babesiosis in North America. Despite the emergence of the disease in recent years, the pathogenesis and immune response to B. microti infection remain poorly understood.
Biniam Hagos, Ioana Brasov, Heather Branscome, Sujatha Rashid, Rebecca Bradford, Joseph Leonelli, Fatah Kashanchi, Choukri Ben Mamoun, Robert E. Molestina   +8 more
doaj   +1 more source

Guarding the frontiers: the biology of type III interferons

Nature Immunology, 2015
Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect them against the frequent viral attacks that are typical for barrier ...
A. Wack, Ewa Terczyńska-Dyla, R. Hartmann   +2 more
semanticscholar   +1 more source

TGF-β inhibitor SB431542 suppresses SARS-CoV-2 replication through multistep inhibition

Journal of Virology
The coronavirus disease 2019 (COVID-19) pandemic highlighted the critical need for broad-spectrum antivirals with high resistance barriers. Here, we demonstrate that SB431542, a selective TGF-β receptor I (ALK5) inhibitor, exhibits potent antiviral ...
Assim Verma, Himanshu Kamboj, Garvit Kumar, Nitin Khandelwal, Benjamin E. Mayer, Jitender Rathee, Yogesh Chander, Alka Nokhwal, Shweta Dhanda, Ram Kumar, Ramesh Kumar Dedar, Sandeep Kumar Bejjanki, Deepti Parashar, Gayathri Pananghat, Bhupendra Nath Tripathi, Riyesh Thachamvally, Shalini Sharma, Naveen Kumar   +17 more
doaj   +1 more source

Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities

, 2018
New technologies have enabled the investigation of biology and human health at an unprecedented scale and in multiple dimensions. These dimensions include a myriad of properties describing genome, epigenome, transcriptome, microbiome, phenotype, and ...
Goldenberg, Anna, Hoffman, Michael M., Leskovec, Jure, Nguyen, Francis, Wang, Bo, Zitnik, Marinka   +5 more
core   +1 more source

Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology

Pharmacological Reviews, 2017
The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel BoNTs are being discovered owing to next generation sequencing, but their biologic and pharmacological properties remain largely unknown.
M. Pirazzini, O. Rossetto, R. Eleopra, C. Montecucco   +3 more
semanticscholar   +1 more source

Scientific photography and animal behaviour: A historical perspective

Mètode Science Studies Journal: Annual Review
Louis Daguerre imagined that his invention would be useful mainly for artistic purposes or for personal use (portraits and travel diaries, etc.), but in fact photography soon became a valuable ally of science. The observation and documentation of natural
Enrique Font
doaj   +1 more source

Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements. [PDF]

, 2009
The biology of both normal and tumor development clearly possesses overlapping and parallel features. Oncogenes and tumor suppressors are relevant not only in tumor biology, but also in physiological developmental regulators of growth and differentiation.
Ho, Allen L, Hughes, Samuel, Jandial, Rahul, Levy, Michael L, Menon, Jayant   +4 more
core   +3 more sources