Results 71 to 80 of about 16,440,357 (384)

Functional Implications of DNA Methylation in Adipose Biology. [PDF]

, 2019
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role ...
Kang, Sona, Ma, Xiang
core  

Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology

Scientific Reports, 2015
Human PIWI-interacting RNAs (piRNAs) are known to be expressed in germline cells, functionally silencing LINEs and SINEs. Their expression patterns in somatic tissues are largely uncharted.
Victor D. Martinez, E. Vucic, K. Thu, Roland Hubaux, Katey S. S. Enfield, L. Pikor, Daiana D. Becker-Santos, Carolyn J. Brown, S. Lam, W. Lam   +9 more
semanticscholar   +1 more source

Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications

Endocrine reviews, 2020
Individuals with diabetes are at increased risk for bacterial, mycotic, parasitic and viral infections. The severe acute respiratory syndrome (SARS)-CoV2 (also referred to as COVID-19) coronavirus pandemic highlights the importance of understanding ...
D. Drucker
semanticscholar   +1 more source

Characterizing Parental Concerns About Lasting Impacts of Treatment in Children With B‐Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker, Sarah W. Alexander, Lisa M. Jacola, Kimberly A. Buff, Kyobin Hwang, Elham Hashemi, Gregory Stoddard, Lindsay A. Jibb   +7 more
wiley   +1 more source

Cell-type-specific resolution epigenetics without the need for cell sorting or single-cell biology. [PDF]

, 2019
High costs and technical limitations of cell sorting and single-cell techniques currently restrict the collection of large-scale, cell-type-specific DNA methylation data.
Barcellos, Lisa F, Criswell, Lindsey A, Eskin, Eleazar, Halperin, Eran, Rahmani, Elior, Rhead, Brooke, Rosset, Saharon, Sankararaman, Sriram, Schweiger, Regev   +8 more
core  

Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus

Endocrine reviews, 2016
The steep rise of type 2 diabetes mellitus (T2DM) and associated complications go along with mounting evidence of clinically important sex and gender differences.
A. Kautzky-Willer, J. Harreiter, G. Pacini   +2 more
semanticscholar   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Bounds for Tur\'anians of modified Bessel functions

, 2013
Motivated by some applications in applied mathematics, biology, chemistry, physics and engineering sciences, new tight Tur\'an type inequalities for modified Bessel functions of the first and second kind are deduced.
Alexandrov, Amos, Baricz, Baricz, Baricz, Baricz, Baricz, Baricz, Baricz, Baricz, Baricz, Bertini, Bhattacharya, Erdélyi, Fabrizi, Giorgi, Giorgi, Grandison, Gronwall, Hamsici, Hamsici, Hamsici, Hartman, Hartman, Hartman, Hasan, Ismail, Ismail, Ismail, Joshi, Klimek, Kokologiannaki, Laforgia, Laforgia, Lechleiter, Lombardo, Lorch, Lushnikov, Marchand, Marchand, Marchand, Nasell, Paltsev, Penfold, Phillips, Radwan, Radwan, Robert, Schlenk, Segura, Simitev, Simon, Tanabe, Thabane, Thiruvenkatachar, van Haeringen, Watson, Watson, Árpád Baricz   +58 more
core   +1 more source

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

Journal of experimental & clinical cancer research : CR, 2019
The extracellular matrix (ECM) plays an important role in cancer progression. It can be divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior and the interstitial matrix (IM) that supports the underlying stromal ...
N. Nissen, M. Karsdal, N. Willumsen
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source