Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology
The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel BoNTs are being discovered owing to next generation sequencing, but their biologic and pharmacological properties remain largely unknown.
M. Pirazzini+3 more
semanticscholar +1 more source
Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications
Individuals with diabetes are at increased risk for bacterial, mycotic, parasitic and viral infections. The severe acute respiratory syndrome (SARS)-CoV2 (also referred to as COVID-19) coronavirus pandemic highlights the importance of understanding ...
D. Drucker
semanticscholar +1 more source
The dual nature of TDC – bridging dendritic and T cells in immunity
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source
Bridging Physics and Biology Teaching through Modeling [PDF]
As the frontiers of biology become increasingly interdisciplinary, the physics education community has engaged in ongoing efforts to make physics classes more relevant to life sciences majors. These efforts are complicated by the many apparent differences between these fields, including the types of systems that each studies, the behavior of those ...
arxiv +1 more source
Guidelines for reporting cell types: the MIRACL standard [PDF]
Cell types are at the root of modern biology, and describing them is a core task of the Human Cell Atlas project. Surprisingly, there are no standards for reporting new cell types, leading to a gap between classes mentioned in biomedical literature and the Cell Ontology, the primary registry of cell types.
arxiv
Functional Implications of DNA Methylation in Adipose Biology. [PDF]
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role ...
Kang, Sona, Ma, Xiang
core
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali+3 more
wiley +1 more source
Variation in some characters of the genus Sceliphron (Hymenoptera: Sphecidae) in the Philippines
The observed morphological and color variations for Sceliphron species in the Philippines are hereby reported. Sceliphron madraspatanum conspicillatum and Sceliphron rufopictum laticinctum have several variations in propodeal maculation pattern and in ...
Kristine O. Abenis+3 more
doaj
Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities [PDF]
New technologies have enabled the investigation of biology and human health at an unprecedented scale and in multiple dimensions. These dimensions include a myriad of properties describing genome, epigenome, transcriptome, microbiome, phenotype, and lifestyle.
arxiv +1 more source
Community and Population Dynamics of Diatoms in Recovering Agricultural Stream and Ubiquitous Taxon in Low-Impact Sites Across Southeastern United States [PDF]
Streams play vital roles to surrounding communities and provide essential ecosystem services. The protection of streams is important, legally protected under the Clean Water Act (CWA) and can be monitored through the continuous analyses of biological ...
Brown, Sydney
core