Results 271 to 280 of about 646,289 (312)
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Cancer, 1995
Type I collagen is a major constituent of the interstitial connective tissue. Although ovarian carcinoma is known to induce the expression of type I collagen in the peritoneal cavity, the distribution and metabolic activity of this collagen in ovarian tumor tissue are not known.The distributions and staining intensities of different molecular forms of ...
G G, Zhu +5 more
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Type I collagen is a major constituent of the interstitial connective tissue. Although ovarian carcinoma is known to induce the expression of type I collagen in the peritoneal cavity, the distribution and metabolic activity of this collagen in ovarian tumor tissue are not known.The distributions and staining intensities of different molecular forms of ...
G G, Zhu +5 more
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Targeting type I collagen for cancer treatment
International Journal of Cancer, 2022AbstractCollagen is the most abundant protein in animals. Interactions between tumor cells and collagen influence every step of tumor development. Type I collagen is the main fibrillar collagen in the extracellular matrix and is frequently upregulated during tumorigenesis.
Run Shi +7 more
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Intermolecular interactions in type I collagens
Journal of Molecular Recognition, 1992AbstractX‐PLOR modelling of collagen dimers containing Gly‐Glu‐Arg in each chain has been carried out. The interaction between molecules when two Gly_Glu‐Arg are present on each chain is found to be substantially less than two times that obtained with one per chain, implying that relative tilting of two collagen molecules does not offset the ...
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Dual Effects of Type II Collagen on the Degradation of Type I Collagen by Tadpole Collagenase
Collagen and Related Research, 1981Kinetic analysis of the degradation of mixtures of type I and type II collagens by tadpole collagenase was performed, using [14C]glycine-labeled type I collagen and [3H]acetylated type II collagen as substrates. The degradation rate of type I collagen was decreased in the initial stage of the reaction, then further slowed down giving a constant rate ...
H, Sunada, T, Hayashi, H, Hori, Y, Nagai
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Comparison of Axial Banding Patterns in Fibrils of Type V Collagen and Type I Collagen
Collagen and Related Research, 1987Type V collagen and type I collagen were obtained from human placenta, essentially by salt fractionation. Precipitates were formed from mixed solutions of type V collagen and type I collagen in various ratios. They were incubated at 37 degrees C for 1 hour and negatively stained with 0.5% uranyl acetate (pH 4.4) at 37 degrees C.
E, Adachi, T, Hayashi
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Synthetic Collagen Heterotrimers: Structural Mimics of Wild-Type and Mutant Collagen Type I
Journal of the American Chemical Society, 2008Collagen type I is an AAB heterotrimer assembled from two alpha1 chains and one alpha2 chain. Missense mutations in either of these chains that substitute a glycine residue in the ubiquitous X-Y-Gly repeat with a bulky amino acid leads to osteogenesis imperfecta (OI) of varying severity. These mutations have been studied in the past using collagen-like
Varun, Gauba, Jeffrey D, Hartgerink
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Distribution of type I collagen in human kidney diseases in comparison with type III collagen
The Journal of Pathology, 1990AbstractThe distribution of type I collagen in normal and diseased renal tissues was studied using immunofluorescence and immunoelectron microscopy, and was compared with that of type III collagen. In normal human kidneys, a monoclonal antibody against type I or type III collagen reacted with the renal interstitium, but not with the intra‐glomerular ...
K, Yoshioka +6 more
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Interaction of Type I Collagen with Phosphatidylcholine Vesicles
Collagen and Related Research, 1988Type I collagen interacts with phosphatidylcholine vesicles. This conclusion has been obtained after ultracentrifugation, fluorescence polarization, circular dichroism and differential scanning calorimetry studies. The protein conformation is not modified by the presence of phospholipids.
A, Martinez del Pozo +3 more
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Binding of type-I collagen to Chlamydia trachomatis
Microbial Pathogenesis, 1994Denatured type-I collagen was found to bind to Chlamydia trachomatis elementary bodies (EBs) in a time-dependent and specific manner. Specificity was tested by having a large excess of other proteins present in the binding mixture. Only denatured type-I collagen efficiently competed for binding.
G, Fröman +3 more
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Antibody to Collagen Type I in Periodontal Disease
Journal of Periodontology, 1986Serum antibody levels to human collagen Type I were measured in 97 patients with periodontal disease (Russell Periodontal Index 1.0–7.0) and 57 control subjects (Periodontal Index <1.0) using an enzyme‐linked immunosorbent assay, which had been standardized with antisera prepared against human collagen Type I in rabbits. Absorption studies were used
A, Ftis, G, Singh, A E, Dolby
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