Results 21 to 30 of about 646,289 (312)
Altered collagen I and premature pulmonary embryonic differentiation in patients with OI type II
Physiological Reports, 2023 Pulmonary hypoplasia and respiratory failure are primary causes of death in patients with osteogenesis imperfecta (OI) type II. OI is a genetic skeletal disorder caused by pathogenic variants in genes encoding collagen type I.
S. Storoni +9 more
doaj +1 more source
Biochemical markers of bone collagen type I metabolism [PDF]
The Ukrainian Biochemical Journal, 2015 This review focuses on the analysis of diagnostic value of the major bone remodeling markers, in particular synthesis and degradation markers of collagen type I.
O. V. Zaitseva +2 more
doaj +1 more source
Scientific Reports, 2022 Intrahepatic cholangiocarcinoma (iCCA) arises along the peripheral bile ducts and is often accompanied by a tumor microenvironment (TME) high in extracellular matrices (ECMs).
Chotirat Rattanasinchai +2 more
doaj +1 more source
Lung collagens perpetuate pulmonary fibrosis via CD204 and M2 macrophage activation. [PDF]
PLoS ONE, 2013 Idiopathic pulmonary fibrosis is characterized by abundant collagen production and accumulation of alternatively activated macrophages (M2) in the lower respiratory tract.
Mirjam Stahl +6 more
doaj +1 more source
Cells, 2022 Idiopathic pulmonary fibrosis is a chronic intractable lung disease, leading to respiratory failure and death. Although anti-fibrotic agents delay disease progression, they are not considered curative treatments, and alternative modalities have attracted
Daisuke Okuno +11 more
doaj +1 more source
BEVACIZUMAB EFFECT ON EXPRESSION OF COLLAGEN TYPE I AFTER TRABECULECTOMY
Journal of Stem Cell Research and Tissue Engineering, 2022 Objective to determine the effect of bevacizumab as an antifibrotic agent on collagen density, collagen thickness and collagen type I after trabeculectomy in rabbit.
Shinta Shinta Arta Wiguna
doaj +1 more source
Active synthesis of type I collagen homotrimer in Dupuytren's fibrosis is unaffected by anti-TNF-α treatment. [PDF]
JCI InsightDupuytren’s disease is a common fibroproliferative disease of the palmar fascia of the hand, with advanced cases treated surgically. Anti-TNF injection has undergone phase 2 trials and may be effective in slowing early-stage disease progression.
Williamson K +15 more
europepmc +2 more sources
Thoracic Cancer, 2019 Background Extracellular matrix (ECM) is remodeled during carcinogenesis. An abundant constituent of ECM is collagen. Type I collagen is secreted by fibroblasts, is important for tumor growth and epithelial‐mesenchymal transition, and may also be ...
Shuo Fang +7 more
doaj +1 more source
Microorganisms, 2023 During skin aging, the production of extracellular matrix (ECM) proteins, such as type I collagen, decreases and the synthesis of ECM-degrading matrix metalloproteinases (MMPs) rises, leading to an imbalance in homeostasis and to wrinkle formation.
Laura Huuskonen +3 more
doaj +1 more source
Regenerative Therapy, 2018 Keratinocyte line cells HaCaT and FEPE1L-8 are used for skin model with type I collagen fibrils (gels). For this purpose, not only differentiation but also regulation of proliferation on type I collagen gels by exogenous calcium concentration is ...
Hitomi Fujisaki +6 more
doaj +1 more source