Results 61 to 70 of about 29,172,517 (275)
Journal of Pathology Informatics, 2011 Increased type I error resulting from multiple statistical comparisons remains a common problem in the scientific literature. This may result in the reporting and promulgation of spurious findings.
Kyle Lesack, Christopher Naugler
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Indian Journal of PsychiatryIn research, outcomes are often categorized as primary and secondary. The primary outcome is the most important one; it determines whether the study is considered ‘successful’ or not. Secondary outcomes are chosen because they provide supporting evidence
Vikas Menon +2 more
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Erratum regarding “Optimizing effective numbers of tests by vine copula modeling”
Dependence Modeling, 2020 We correct the definition of the family-wise error rate in our previous article “Optimizing effective numbers of tests by vine copula modeling”.
Steffen Nico, Dickhaus Thorsten
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Curbing type I and type II errors [PDF]
European Journal of Epidemiology, 2010 The statistical education of scientists emphasizes a flawed approach to data analysis that should have been discarded long ago. This defective method is statistical significance testing. It degrades quantitative findings into a qualitative decision about the data.
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Control of Type 1 and Type 2 Errors in Configural Frequency Analysis
Journal for Person-Oriented ResearchIn this article, standard configural frequency analysis (CFA) is compared with combinatorial Victor CFA with respect to Type I errors and power. Victor CFA is most important and suitable when phantom types or phantom antitypes are suspected to exist ...
Stefan von Weber, Alexander von Eye
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Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source