Results 81 to 90 of about 29,172,517 (275)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Badly Controlled Type I error.
, 2023 Methods (X axis) that had an inflated type I error for experiment ID n°4 (Table 1) and their type I error (Y axis) at nominal level α = 0.05 based on 10 000 replicates.
Miikka Vikkula (33969) +3 more
core +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
, 2023 Methods (X axis) that have a good type I error for experiment ID n°4 (Table 1) and their type I error (Y axis) at nominal level α = 0.05, based on 10 000 replicates.
Miikka Vikkula (33969) +3 more
core +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
پژوهشهای ریاضی, 2022 In this paper, we consider the problem of two sided hypothesis testing for the parameter of coefficient of variation of an inverse Gaussian population.
Mohammad Reza Kazemi
doaj
Al-Iqtishad: Jurnal Ilmu Ekonomi Syariah, 2019 The paper applies normal approximation procedure to binomial probability distribution. A sample of 392 respondents are surveyed whether they agree or not agree that promotional activities determined the level of awareness of benefits of Islamic mutual ...
Mohd Yaziz Bin Mohd Isa
doaj +1 more source