Results 71 to 80 of about 13,800,549 (299)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Features pharmacotherapy of Diabetes Mellitus II type

Annals of Mechnikov's Institute, 2020
Epidemiological increased incidence of diabetes mellitus is still ongoing. Treatment of patients with diabetes mellitus is challenging due to several factors: low level of diagnostics, difficulties in choice of drugs, the limited use of self-monitoring ...
N Tryshchuk
doaj  

Respiratory Myopathy in Type II Diabetes Mellitus [PDF]

Journal of Clinical and Diagnostic Research, 2012
Background and Objectives: The incidence of Type II diabetes mellitus is on the rise in developing countries. It is well known that this metabolic disorder leads to a variety of multi-system complications, mainly in the eye, kidney, heart, and the ...
Nandhini R., Syed Safina S.S., Saikumar P.   +2 more
doaj  

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Salivary IgA concentration in diabetic patients compared to healthy controls

Dental Hypotheses, 2015
Introduction: The alterations in salivary flow rate and its compositions could affect the development, symptoms, and severity of oral changes in diabetic patients.
Farimah Sardari, Afshin Tahmasbi, Arash Ghanbarzadegan   +2 more
doaj   +1 more source

Acute hypoglycemia impairs executive cognitive function in adults with and without type 1 diabetes [PDF]

, 2013
OBJECTIVE Acute hypoglycemia impairs cognitive function in several domains. Executive cognitive function governs organization of thoughts, prioritization of tasks, and time management.
Graveling, Alex J., Deary, Ian J., Frier, Brian M.   +2 more
core   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

IRISIN, OBESITY AND TYPE II DIABETES MELLITUS

International Journal of Pharmacy & Integrated Health Sciences
Background: Irisin is an exercise-induced cytokine that is expressed as a biologically active peptide in many organs and tissues. Physical exercise and coldness are the main triggers for irisin release.
Zainab Fathi, Jehan A Mohammad, Mayadah H.Al Jammas, Ban Ali   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source