Results 51 to 60 of about 13,800,549 (299)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effects of yogurt and yogurt plus shallot consumption on lipid profiles in type 2 diabetic women

International Journal of Preventive Medicine, 2017
Background: Identification of food with lowering cholesterol level properties plays a vital role to control impaired lipid profile among type 2 diabetic patients. the current study aimed to evaluate the effects of yogurt and yogurt plus shallot intake on
Sanaz Mehrabani, Behnod Abbasi, Leila Darvishi, Mehdi Asemi Esfahani, Zahra Maghsoudi, Hossein Khosravi-Boroujeni, Reza Ghiasvand   +6 more
doaj   +1 more source

Association between BMI measured within a year after diagnosis of type 2 diabetes and mortality [PDF]

, 2013
OBJECTIVE: To describe the association of BMI with mortality in patients diagnosed with type 2 diabetes. RESEARCH DESIGN AND METHODS: Using records of 106,640 patients in Scotland, we investigated the association between BMI recorded around the diagnosis
McKnight, J., Walker, Jeremy J., Morris, A., Sattar, N, Sattar, N., Wild, S., McKnight, J, Philip, Sam, Morris, Andrew, Wild, Sarah, Lindsay, R., Leese, Graham, Walker, JJ, Leese, G, McKnight, John, Group, Scottish Diabetes Research Network Epidemiology, Morris, A, Walker, J.J., Lindsay, Robert, Leese, G., Sattar, Naveed, Logue, J., Philip, S, Logue, J, Wild, Sarah; id_orcid, ?, ?, Logue, Jennifer, Walker, Jeremy J, Philip, S., Lindsay, R, Wild, S   +30 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

FEATURES PHARMACOTHERAPY OF DIABETES MELLITUS II TYPE [PDF]

Annals of Mechnikov's Institute, 2014
Epidemiological increased incidence of diabetes mellitus is still ongoing. Treatment of patients with diabetes mellitus is challenging due to several factors: low level of diagnostics, difficulties in choice of drugs, the limited use of self ...
Tryshchuk N. M.
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

OSSEOINTEGRATION OF DENTAL IMPLANT IN TYPE I & TYPE II DIABETIC PATIENTS (A COMPARATIVE CLINICAL TRIAL) [PDF]

Alexandria Dental Journal
Background: Osseointegration is the process by which a load-bearing implant becomes structurally and functionally fused with organized, living bone. Diabetes mellitus (DM) is a metabolic condition in which abnormalities in insulin synthesis, insulin ...
Sultan Alwah, Hala Ragab, Dina Metawie
doaj   +1 more source

Role of metformin in type II diabetes

Cleveland Clinic Journal of Medicine, 1995
When diet and exercise fail to control type II diabetes, metformin promotes control of blood sugar levels.
W. S. Wilke, S. Epstein
openaire   +2 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source