Results 91 to 100 of about 25,865 (227)

On the role of the sorting platform in hierarchical type III secretion regulation in enteropathogenic Escherichia coli

Journal of Bacteriology
The virulence of enteropathogenic Escherichia coli (EPEC) depends on a type III secretion system (T3SS), a membrane-spanning apparatus that injects effector proteins into the cytoplasm of target enterocytes.
Arely Marcos-Vilchis, Norma Espinosa, Adrián F. Alvarez, José L. Puente, J. Eduardo Soto, Bertha González-Pedrajo   +5 more
doaj   +1 more source

The absence of protein Y4yS affects negatively the abundance of T3SS Mesorhizobium loti secretin, RhcC2, in bacterial membranes

Frontiers in Plant Science, 2015
Mesorhizobium loti MAFF303099 has a functional type III secretion system (T3SS) that is involved in the determination of nodulation competitiveness on Lotus. The M.
Virginia eMercante, Cecilia M. Duarte, Cintia M. Sánchez, Andrés eZalguizuri, Gustavo eCaetano-Anollés, Viviana C. Lepek   +5 more
doaj   +1 more source

Spermidine Is an Intercellular Signal Modulating T3SS Expression in Pseudomonas aeruginosa

Microbiology Spectrum, 2022
Pseudomonas aeruginosa is a vital opportunistic human bacterial pathogen that causes acute and chronic infections. In this study, we set to determine whether the endogenous spermidine biosynthesis plays a role in regulation of type III secretion system ...
Qiqi Lin, Huishan Wang, Jiahui Huang, Zhiqing Liu, Qunyi Chen, Guohui Yu, Zeling Xu, Ping Cheng, Zhibin Liang, Lian-Hui Zhang   +9 more
doaj   +1 more source

Structure of a bacterial type III secretion system in contact with a host membrane in situ [PDF]

, 2015
Many bacterial pathogens of animals and plants use a conserved type III secretion system (T3SS) to inject virulence effector proteins directly into eukaryotic cells to subvert host functions. Contact with host membranes is critical for T3SS activation,
A Diepold, A Dubrovsky, A Kawamoto, A Loquet, A Martinez-Sanchez, A Nans, A Veenendaal, AS Frangakis, B Chellas-Gery, B Hu, C Epier, C Montagner, CA Mueller, CK Yip, D Castaño-Díez, D Harmon, DN Mastronarde, F Sievers, FFV Chevance, GR Cornelis, GW Liechti, HJ Betts-Hampikian, J Kowal, J Radics, J Wickstrum, JE Deane, JE Galán, JF Kim, JL Cocchiaro, JL Hodgkinson, JR Kremer, JRC Bergeron, KA Fields, KE Spaeth, L Journet, M Kudryashev, M Kudryashev, M Lara-Tejero, MK Zierler, O Schraidt, P Abrusci, P Kosma, Q Xiong, R Ménard, S Chatterjee, S Pruggnaller, S Rund, SS Abby, T Spreter, T Tosi, TC Marlovits, WP Jamison, Y Akeda, Y Wang   +53 more
core   +3 more sources

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

The FEBS Journal, EarlyView.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima, Dev Sriranganadane, Daiane Laise da Silva, Natália C. Drebes Dörr, Enzo Breviglieri Sichi Mello, Caio Vinicius dos Reis, Rogério Ferreira Lourenço, José Felipe Teixeira da Silva Santos, Anita Salmazo, Brenno Wendler Miranda, Katlin B. Massirer, Rafael M. Couñago, Cristina E. Alvarez‐Martinez   +12 more
wiley   +1 more source

Lon Protease Is Involved in RhpRS-Mediated Regulation of Type III Secretion in Pseudomonas syringae

Molecular Plant-Microbe Interactions, 2016
Pseudomonas syringae depends on the type III secretion system (T3SS) to directly translocate effectors into host cells. Previously, we reported a nonpathogenic rhpS mutant, suggesting that the two-component transduction system rhpRS is an important ...
Tianhong Zhou, Chunyan Yin, Yingchao Zhang, Heng Shi, Jingru Wang, Linbo Sun, Xiaolong Shao, Ruxia Gao, Wei Wang, Xin Deng   +9 more
doaj   +1 more source

Type III secretion system expression in oxygen-limited Pseudomonas aeruginosa cultures is stimulated by isocitrate lyase activity [PDF]

Open Biology, 2013
Pseudomonas aeruginosa is an opportunistic human pathogen and a common cause of chronic infections in individuals with cystic fibrosis (CF). Oxygen limitation was recently reported to regulate the expression of a major virulence determinant in P ...
Jade C. S. Chung, Olena Rzhepishevska, Madeleine Ramstedt, Martin Welch   +3 more
doaj   +1 more source

Novel Disk Diffusion Assay on Magnesium Oxalate Agar To Evaluate the Susceptibility of Yersinia pestis to Type III Secretion System Inhibitors

Microbiology Spectrum, 2021
Current methods for screening small molecules that inhibit the plasmid pCD1-encoded Yersinia pestis type III secretion system (T3SS) include lengthy growth curves followed by multistep luminescence assays or Western blot assays to detect secretion, or ...
Sukriti Prashar, Miguel Portales Guemes, Poorandai Shivbaran, Eugenia Jimenez Alvarez, Christopher Soha, Samir Nacer, Michael McDonough, Gregory V. Plano, Julie Torruellas Garcia   +8 more
doaj   +1 more source

NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. [PDF]

, 2016
NLRs (nucleotide-binding domain [NBD] leucine-rich repeat [LRR]-containing proteins) exhibit diverse functions in innate and adaptive immunity.
Al Moussawi, Khatoun, Kang, Chulho, Kang, James J, Kazmierczak, Barbara I, Nichols, Randilea D, Rauch, Isabella, Tenthorey, Jeannette L, Vance, Russell E   +7 more
core   +1 more source

PopB-PcrV Interactions Are Essential for Pore Formation in the Pseudomonas aeruginosa Type III Secretion System Translocon

bioRxiv, 2022
Type III secretion systems are integral to the pathogenesis of many Gram-negative bacterial pathogens. A hallmark of these secretion systems is that they deliver effector proteins vectorially into the targeted host cell via a translocation pore. ABSTRACT
E. Kundracik, Josephine Trichka, José Enrique Díaz Aponte, Alicia Roistacher, A. Rietsch   +4 more
semanticscholar   +1 more source