Results 131 to 140 of about 25,865 (227)

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, Volume 13, Issue 8, 9 February 2026.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source

NrtR Regulates the Type III Secretion System Through cAMP/Vfr Pathway in Pseudomonas aeruginosa

Frontiers in Microbiology, 2019
The type III secretion system (T3SS) plays an important role in the pathogenesis of Pseudomonas aeruginosa. Expression of the T3SS is controlled under a complicate regulatory network.
Yongxin Jin, Mengjing Zhang, Feng Zhu, Qianqian Peng, Yuding Weng, Qiang Zhao, Chang Liu, Fang Bai, Zhihui Cheng, Shouguang Jin, Weihui Wu   +10 more
doaj   +1 more source

Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen burkholderia pseudomallei K96243 [PDF]

, 2010
Burkholderia pseudomallei is an important human pathogen whose infection biology is still poorly understood. The bacterium is endemic to tropical regions, including South East Asia and Northern Australia, where it causes melioidosis, a serious disease ...
Bentley, Stephen D., Dowling, Andrea J., ffrench-Constant, Richard H., Holden, Matthew T. G., Quail, Michael A., Reger, Julia, Titball, Richard W., Waterfield, Nicholas R., Wilkinson, Paul A.   +8 more
core   +7 more sources

Genomic Surveillance of Epiphytic Pseudomonas syringae Highlights Shared Reservoirs and Cross‐Habitat Threats to Cherry Orchards and Nearby Woodland Plants

Molecular Plant Pathology, Volume 27, Issue 2, February 2026.
Highly virulent epiphytic Pseudomonas syringae PG2d strains are widespread in UK cherry orchards and woodlands, varying in abundance and threatening domestic and wild cherry health. ABSTRACT Plant surfaces host diverse microbial communities acting as reservoirs for pathogenic lineages, yet the ecological dynamics and evolutionary consequences of such ...
Ziyue Zeng, John W. Mansfield, Andrea Vadillo‐Dieguez, John Connell, James Irvine, Michelle T. Hulin, Fernando Duarte Frutos, Mojgan Rabiey, Nastasiya F. Grinberg, Richard J. Harrison, Xiangming Xu, Robert W. Jackson   +11 more
wiley   +1 more source

Chlamydial infection from outside to inside [PDF]

, 2019
Chlamydia are obligate intracellular bacteria, characterized by a unique biphasic developmental cycle. Specific interactions with the host cell are crucial for the bacteria's survival and amplification because of the reduced chlamydial genome.
Gitsels, Arlieke, Sanders, Niek, Vanrompay, Daisy   +2 more
core   +2 more sources

Additional file 1: of Computational approach to predict species-specific type III secretion system (T3SS) effectors using single and multiple genomes

, 2016
Statistical analysis of the 21 attributes for the four organisms used in this studies. SD denotes standard deviation. Attribute values that have statistically significant differences between the positive and negative sets are highlighted. (DOCX 25 kb)
Hobbs, Christopher, Porter, Vanessa, Stow, Maxwell, Bupe Siame, Tsang, Herbert, Leung, Ka   +5 more
openaire   +1 more source

Type IV Pili Can Mediate Bacterial Motility within Epithelial Cells. [PDF]

, 2019
Pseudomonas aeruginosa is among bacterial pathogens capable of twitching motility, a form of surface-associated movement dependent on type IV pili (T4P). Previously, we showed that T4P and twitching were required for P.
Evans, David J, Fleiszig, Suzanne MJ, Grosser, Melinda R, Hagan, Patrick, Hallsten, Mary E, Kroken, Abby R, Metruccio, Matteo ME, Nieto, Vincent, Smith, Benjamin E   +8 more
core   +2 more sources

Additional file 5: of Computational approach to predict species-specific type III secretion system (T3SS) effectors using single and multiple genomes

, 2019
A brief protocol on the setting up GenSET for T3SS effector prediction customized for other gram-negative genomes. (DOCX 40 kb)
Hobbs, Christopher, Porter, Vanessa, Stow, Maxwell, Bupe Siame, Tsang, Herbert, Leung, Ka   +5 more
openaire   +1 more source

Comparative Analysis of the Type III Secretion System Effector Repertoires of Pseudomonas savastanoi Pathovars Pathogenic on Woody Hosts [PDF]

, 2017
Comunicación de tipo pósterThe species Pseudomonas savastanoi, a member of the Pseudomonas syringae complex, includes four pathovars causing knots or excrescences in woody hosts: P. savastanoi pv. savastanoi (Psv), pv. fraxini (Psf), pv.
Castañeda-Ojeda, M. Pilar, López-Solanilla, Emilia, Moreno-Pérez, Alba, Murillo, Jesús, Ramos, Cayo, Rodríguez-Palenzuela, Pablo   +5 more
core  

Structures of chaperone-substrate complexes docked onto the export gate in a type III secretion system

Nature Communications, 2018
The flagellum and the injectisome enable bacterial locomotion and pathogenesis, respectively. These nanomachines assemble and function using a type III secretion system (T3SS).
Qiong Xing, Ke Shi, Athina G. Portaliou, Paolo Rossi, Anastassios Economou, C. Kalodimos   +5 more
semanticscholar   +1 more source