Results 111 to 120 of about 18,345,299 (284)

Identification of a new export signal that targets early subunits to the flagellar type III secretion export machinery

mBio
Type III secretion systems (T3SSs) are essential for motility and virulence in many bacterial pathogens. Proteins destined for the flagellar T3SS contain at least two export signals in their N-terminal D0 domain.
Owain J. Bryant, Gillian M. Fraser
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Multiple nucleic acid cleavage modes in divergent type III CRISPR systems [PDF]

, 2016
CRISPR-Cas is an RNA-guided adaptive immune system that protects bacteria and archaea from invading nucleic acids. Type III systems (Cmr, Csm) have been shown to cleave RNA targets in vitro and some are capable of transcription-dependent DNA targeting ...
Zhang, Jing, White, Malcolm Frederick, Tello, Agnes, Liu, Huanting, Graham, Shirley   +4 more
core   +1 more source

Virulence factors and integrons are associated with MDR and XDR phenotypes in nosocomial strains of Pseudomonas aeruginosa in a Venezuelan university hospital

Revista do Instituto de Medicina Tropical de São Paulo, 2019
Multidrug resistance (MDR), virulence and transferable elements potentiate Pseudomonas aeruginosa's role as an opportunistic pathogen creating a high risk for public health.
Hectorina Rodulfo, Anlenys Arcia, Aldo Hernández, Elvia Michelli, Dianny del Valle Martinez, Militza Guzman, Ashutoch Sharma, Marcos De Donato   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Expression and regulation of the Escherichia coli O157:H7 effector proteins NleH1 and NleH2 [PDF]

, 2012
E. coli O157 carries two genes encoding the effector proteins NleH1 and NleH2 which are 87% identical. Despite the similarity between the proteins, the promoter regions upstream of the genes encoding the effectors are more divergent suggesting that the ...
Mitchell, Tim J, Tim J Mitchell, Tom J Evans, Roe, Andrew J, Wang, Dai, Ashleigh Holmes, Ashleigh Holmes (179132), Dai Wang, Andrew J. Roe (107419), Holmes, Ashleigh, Cecilia S. Lindestam Arlehamn (179138), Lindestam Arlehamn, Cecilia S, Dai Wang (73589), Cecilia S Lindestam Arlehamn, Tom J. Evans (179147), Tim J. Mitchell (179143), Andrew J Roe, Evans, Tom J, Mitchell, T.J., Evans Tom J., Schmidt, E.E., Holmes, A., Roe, A.J., Lindestam Arlehamn, C.S., Roe Andrew J., Wang Dai, Lindestam Arlehamn Cecilia S., Mitchell Tim J., Holmes Ashleigh, Wang, D., Evans, T.J.   +30 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Salmonella bongori provides insights into the evolution of the Salmonellae [PDF]

, 2011
The genus Salmonella contains two species, S. bongori and S. enterica. Compared to the well-studied S. enterica there is a marked lack of information regarding the genetic makeup and diversity of S. bongori. S.
Parkhill Julian, Fookes, M, Maskell, Duncan, Caterina Mammina, Kingsley Robert A., Fookes, M., Santiviago, CA, Gad Frankel, Georgios S. Vernikos, Gemma C Langridge, Fookes Maria, Vernikos, G.S., Baeumler, AJ, Mammina, C, Nuccio Sean-Paul, Nastasi, A., Seth-Smith, Helena, Contreras Inés, Langridge, GC, Nuccio, SP, Contreras I, Keith S. Robinson, Schroeder GN, Seth Smith H, Frankel Gad, Humphrey Tom, Petty NK, Nicola K Petty, Sanders, M., Kingsley, Robert A, Dougan G, Kingsley, R.A., Helena Seth-Smith, Baumler, Andreas J., Sanders M, Thomson N.R., Nastasi, A, Gemma C. Langridge, Barrow P, Paul Barrow, Nicholas R Thomson, Seth-Smith, H., Blondel, Carlos J., Santiviago, Carlos A, Frankel, G, Vernikos GS, Seth-Smith Helena, Vernikos, Georgios S., Thomas R. Connor, Vernikos Georgios S., Petty, Nicola K., Petty, N.K., Maskell D, Nuccio, S.-P., Kingsley RA, Humphrey, T., Blondel, Carlos J, Connor, Thomas Richard, Humphrey, Tom, Andreas J. Bäumler, Contreras, I., Vernikos, GS, Robinson, KS, Blondel, C.J., Santiviago, Carlos A., Julian Parkhill, Langridge, Gemma C, Parkhill J, Langridge Gemma C., Blondel CJ, Dougan, Gordon, Georgios S Vernikos, Parkhill, Julian, Barrow, P., Langridge, G.C., Gunnar N Schroeder, Connor TR, Thomas R Connor, Nuccio, Sean, Maskell, D, Roberts Mark, Santiviago CA, Roberts M, Robinson, K.S., Robinson Keith S., Thomson, NR, Santiviago, C.A., Contreras, Ines, Frankel G, Roberts, M., Fookes M, Robert A Kingsley, Sean-Paul Nuccio, Sanders Mandy, Bäumler AJ, Nuccio, S-P, Parkhill, J, Mammina Caterina, Mammina, Caterina, Sanders, M, Mark Roberts, Bäumler Andreas J., Schroeder, Gunnar N., Contreras, I, Connor, T.R., Vernikos, Georgios S, Langridge, Gemma C., Connor Thomas R., Nastasi, Antonino, Gunnar N. Schroeder, Bäumler, AJ, Gordon Dougan, Barrow, P, Robinson, Keith S., Nuccio, Sean-Paul, Maskell Duncan, Sanders, Mandy, Humphrey, T, Carlos A Santiviago, Petty Nicola K., Barrow Paul, Thomson, Nicholas R, Thomson, Nicholas R., Blondel Carlos J., Robinson, Keith S, Keith S Robinson, Seth-Smith, H, Maria Fookes, Nuccio SP, Dougan, G., Inés Contreras, Petty, NK, Schroeder, Gunnar N, Tom Humphrey, Connor, Thomas R, Langridge GC, Frankel, G., Blondel, CJ, Robert A. Kingsley, Maskell, D., Parkhill, J., Dougan Gordon, Thomson Nicholas R., Carlos A. Santiviago, Roberts, Mark, Frankel, Gad, Schroeder Gunnar N., Robinson KS, Santiviago Carlos A., Nicola K. Petty, Petty, Nicola K, Thomas Humphrey, Mandy Sanders, Mammina, C., Kingsley, Robert A., Kingsley, RA, Connor, Thomas R., Barrow, Paul, Nastasi Antonino, Schroeder, GN, Schroeder, G.N., Thomson, N.R., Roberts, M, Nastasi A, Duncan Maskell, Humphrey T, Andreas J Bäumler, Nicholas R. Thomson, Bäumler, A.J., Carlos J Blondel, Connor, TR, Fookes, Maria, Dougan, G, Carlos J. Blondel, Bäumler, Andreas J, Antonino Nastasi   +175 more
core   +3 more sources

Regulation and inhibition of type III secretion systems in plant pathogenic bacteria

Phytopathology Research
Type III secretion systems (T3SS) are syringe-like apparatuses acting as protein transport nanomachines found in most Gram-negative bacterial pathogens. They can inject effector proteins into the host cell cytoplasm, crossing the host cell membrane, and ...
Muhammad Asif, Xin Xie, Zhibo Zhao
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source