Results 61 to 70 of about 8,720,254 (253)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Type IV Collagen, Type IV Collagenase Activity and Ability of Cell Proliferation in Human Thyroid Tumours [PDF]

, 2002
BackgroundThe processes of malignant tumour invasion and metastasis are known to include the destruction of cell stroma and vascular basement membrane.
Tomura, Takanori, Takao Satou, Saori Kimoto-Kinoshita, Takeshi Kusunoki, Kiyotaka Murata, Nishida, Shozo, Kimoto-Kinoshita, Saori, Murata, Kiyotaka, Satou, Takao, Shozo Nishida, Takanori Tomura, Kusunoki, Takeshi   +11 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Secretion of Type IV Collagen by Keratinocytes of Human Adult [PDF]

, 1985
Secretion of type IV collagen by keratinocytes was studied by anti-type IV collagen immunoglobulin in pure keratinocyte culture of the human adult. The cultivated keratinocytes secreted type IV collagen into the space between skin collagen type I.
Gustav Asboe-Hansen, Takasi Kobayasi, Asboe-Hansen, Gustav, Motoi Oguchi, Kobayasi, Takasi, Oguchi, Motoi   +5 more
core   +1 more source

Novel Biomarker Monoclonal Antibody Fragmentation Collagen Type IV To Detect Acute Myocardial Infarction Related Perviromonas Gingivalis Infection

Majalah Kardiologi Indonesia, 2013
Background. Index mortality of atherosclerotic very high. The research conducted by WHO in 1995 show 20% of IMA mortality caused by ath-erosclerotic. The new emerging risk factor infection is the Perviromonas gingivalis.
Ketut Muliartha, Mulyohadi Ali, Djanggan Sargowo   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hierarchical nanomechanics of collagen microfibrils [PDF]

, 2010
Collagen constitutes one third of the human proteome, providing mechanical stability, elasticity and strength to connective tissues. Collagen is also the dominating material in the extracellular matrix (ECM) and is thus crucial for cell differentiation ...
Alberto Redaelli, Markus J. Buehler, Alfonso Gautieri, Simone Vesentini   +3 more
core  

Distribution of α(IV) collagen chains in the ocular anterior segments of adult mice

, 2011
ArticleThe distribution of the collagen chains from α1(IV) to α6(IV) could serve as a basis for the characterization of type IV collagen. In this study, immunohistochemistry of the ocular anterior segment of adult mice was performed using specific ...
Nomoto, Hiroyuki, 5069, Nakajima, Ai, Saito, Kenji, Morizane, Yuki, Ninomiya, Yoshifumi, MINAGUCHI, Jyun, b3feebe96363a5f7b7ccf1252aa990bd, 5313, Sugimoto, Manabu, 5314, 5315, 5316, 5317, Kusachi, Shozo, 5310, Suetsugu, Shiho, 5311, 5312, Yonezawa, Tomoko, Sado, Yoshikazu, 5307, 5308, Kurosaki, Masae, 5309   +24 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Tribbles 3 Regulates the Fibrosis Cytokine TGF-β1 through ERK1/2-MAPK Signaling Pathway in Diabetic Nephropathy

Journal of Immunology Research, 2014
To reveal the expression and possible role of tribbles homolog 3 (TRB3) in the incidence of type 2 diabetic nephropathy, we used immunohistochemistry, real-time quantitative PCR, western blot analysis, and enzyme-linked immunosorbent assay (ELISA) to ...
Luwei Zhang, Jinhang Zhang, Xinnong Liu, Shengli Liu, Jun Tian   +4 more
doaj   +1 more source