Results 131 to 140 of about 11,396,305 (309)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Electrocapacitive Properties of Cathode Materials Based on Na 3 Fe 2 (PO 4 ) 3 Polycrystals Synthesized by Solid-phase and Melt-quenching Methods

Eurasian Journal of Physics and Functional Materials
The article provides a comparative assessment of the influence of solid-phase and melt-quenching synthesis methods on the structures and electrochemical properties of Na 3 Fe 2(PO 4)3 polycrystals.
Artur A. Nogai, Eleonora A. Nogai , Dina D. Akimbaeva, Adolf S. Nogai , Alexandr A. Bush, Galia G. Tatkeeva, Daniyar E. Uskenbaev   +6 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The synthesis and optical properties of three stilbene-type dyes

, 2008
The synthesis and optical properties of three stilbene-type ...
Chuanxiang Qin (13053834), X Wang (1378959), G Chen (7052081), M Zhou (7793240), W Zhang (5160386)   +4 more
core  

Recent development of the HMM-based speech synthesis system (HTS) [PDF]

, 2009
A statistical parametric approach to speech synthesis based on hidden Markov models (HMMs) has grown in popularity over the last few years. In this approach, spectrum, excitation, and duration of speech are simultaneously modeled by context-dependent ...
Tokuda, Keiichi, Oura, Keiichiro, Toda, Tomoki, Black, Alan W., Sako, Shinji, Zen, Heiga, Yamagishi, Junichi, Black, Alan W, Masuko, Takashi, Nose, Takashi   +9 more
core  

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Automatic Type Synthesis of Planar Kinematic Chain based on the Modified Assur-group Adjacency Matrix Theory

Jixie chuandong, 2016
In order to make it convenient for computer automatic synthesize,the automatic type synthesis of planar kinematic chains with modified Assur-group adjacency matrix is proposed. First of all,aiming at the known amount of the components,the active ones and
Shan Chuncheng, Cao Yi, Liu Kai
doaj  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

A gemini-type superspreader: Synthesis, spreading behavior and superspreading mechanism

, 2017
A gemini-type superspreader: Synthesis, spreading behavior and superspreading ...
Wenli Bai (13099599), MingNing Zhu (14616722), JieXing Chen (14616734), Fuqun Chen (14616731), Wei Wang (17594), Jing Lin (50818), Cheng Zheng (227957), ZhiWei Qiao (14616728), Zili Liu (289909), DongDong Lu (14616725), XianFang Cai (4824318)   +10 more
core