Results 151 to 160 of about 11,396,305 (309)
Irreversible repression of DNA synthesis in Fanconi anemia cells is alleviated by the product of a novel cyclin-related gene [PDF]
, 1995 Primary fibroblasts from patients with the genetic disease Fanconi anemia, which are hypersensitive to cross-linking agents, were used to screen a cDNA library for sequences involved in their abnormal cellular response to a cross-linking challenge.
Digweed, M. +5 more
core
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Design and Synthesis of Fluorescent Probes for Cannabinoid Receptor Type 1
DESIGN AND SYNTHESIS OF FLUORESCENT PROBES FOR CANNABINOID RECEPTOR TYPE 1 Design and Synthesis of Fluorescent Probes for Cannabinoid Receptor Type 1 / Mach, Leonard (Rights reserved) (-
Mach, Leonard
core
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Synthesis And Characterization Of Zeolite Membranes For Binary Gas Separation [QE391.Z5 T161 2007 f rb]. [PDF]
, 2007 Tiga jenis membran zeolit MFI (ZSM-5 dan Silicalite-1) dengan kecacatan minimum telah disintesiskan dengan menggunakan cara yang berlainan. Membran tersebut adalah Silicalite-1 (Si/Al = ∞), Na-ZSM-5 (Si/Al = 25) and B-ZSM-5 (Si/B = 100).
Tan, Sek Choong
core
Type-Directed Program Synthesis for Complex APIs [PDF]
As software systems grow sophisticated, complex APIs are widely used to accelerate program development. However, effectively using these APIs can be challenging due to poor documentation that fails to sufficiently explain API behaviors.
Guo, Zheng
core +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Cities and the Environment, 2008 This article provides an overview on different types of managing interdisciplinary knowledge integration in environmental urban research projects: 1. "synthesis-then", 2. "synthesis-online", 3. "synthesis-first", 4. "synthesis-as contracted".
Hadia Köhler +2 more
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