Results 81 to 90 of about 837,747 (262)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Near conformal perturbation theory in SYK type models

open access: yesJournal of High Energy Physics, 2020
We present a systematic procedure to extract the dynamics of the low energy soft mode in SYK type models with a single energy scale J and emergent reparametrization symmetry in the IR.
Sumit R. Das   +3 more
doaj   +1 more source

Bernays–Gödel type theory

open access: yesJournal of Pure and Applied Algebra, 2003
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Type theories in category theory

open access: yes, 2021
We introduce basic notions in category theory to type theorists, including comprehension categories, categories with attributes, contextual categories, type categories, and categories with families along with additional discussions that are not very closely related to type theories by listing definitions, lemmata (with detailed, diagram-rich proofs ...
openaire   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Introduction to Type Theory [PDF]

open access: yes, 2009
These notes comprise the lecture "Introduction to Type Theory" that I gave at the Alpha Lernet Summer School in Piriapolis, Uruguay in February 2008. The lecture was meant as an introduction to typed ¿-calculus for PhD. students that have some (but possibly not much) familiarity with logic or functional programming.
openaire   +2 more sources

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