Type Three Secretion System in Attaching and Effacing Pathogens [PDF]
Frontiers in Cellular and Infection Microbiology, 2016 Enteropathogenic Escherichia coli and enterohemorrhagic E. coli are diarrheagenic bacterial human pathogens that cause severe gastroenteritis. These enteric pathotypes, together with the mouse pathogen Citrobacter rodentium, belong to the family of ...
Meztlli Ofelia Gaytán +3 more
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Genetic code expansion enables visualization of Salmonella type three secretion system components and secreted effectors [PDF]
eLife, 2021 Type three secretion systems enable bacterial pathogens to inject effectors into the cytosol of eukaryotic hosts to reprogram cellular functions. It is technically challenging to label effectors and the secretion machinery without disrupting their ...
Moirangthem Kiran Singh +3 more
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Baicalin Represses Type Three Secretion System of Pseudomonas aeruginosa through PQS System [PDF]
Molecules, 2021 Therapeutics that target the virulence of pathogens rather than their viability offer a promising alternative for treating infectious diseases and circumventing antibiotic resistance.
Pansong Zhang +7 more
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Delivery of spike-RBD by bacterial type three secretion system for SARS-CoV-2 vaccine development [PDF]
Frontiers in Immunology, 2023 COVID-19 pandemic continues to spread throughout the world with an urgent demand for a safe and protective vaccine to effectuate herd protection and control the spread of SARS-CoV-2. Here, we report the development of a bacterial vector COVID-19 vaccine (
Yuchen Zhou +16 more
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Bordetella bronchiseptica diguanylate cyclase BdcB inhibits the type three secretion system and impacts the immune response [PDF]
Scientific Reports, 2023 Bordetella bronchiseptica is a gram-negative bacterium that causes respiratory diseases in different animals, including mice, making B. bronchiseptica the gold-standard model to investigate host–pathogen interaction at the molecular level.
Keila Belhart +3 more
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Functional characterization of a gamma-glutamyl phosphate reductase ProA in proline biosynthesis and promoting expression of type three secretion system in Ralstonia solanacearum [PDF]
Frontiers in Microbiology, 2022 Ralstonia solanacearum RSc2741 has been predicted as a gamma-glutamyl phosphate reductase ProA catalyzing the second reaction of proline formation from glutamate.
Yue Guan +9 more
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Multitask Approach to Localize Rhizobial Type Three Secretion System Effector Proteins Inside Eukaryotic Cells [PDF]
Plants, 2023 Rhizobia can establish mutually beneficial interactions with legume plants by colonizing their roots to induce the formation of a specialized structure known as a nodule, inside of which the bacteria are able to fix atmospheric nitrogen.
Irene Jiménez-Guerrero +2 more
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Identification of Novel Type Three Secretion System (T3SS) Inhibitors by Computational Methods and Anti-Salmonella Evaluations [PDF]
Frontiers in Pharmacology, 2021 Three type III secretion system (T3SS) inhibitors (compounds 5, 19, and 32) were identified by virtual screening and biological evaluation. These three compounds were evaluated against a panel of Salmonella species strains including S.
Yonghui Wang +6 more
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The bacterial type three secretion system induces mechanoporation of vacuolar membranes. [PDF]
PLoS BiologyEndomembrane breaching is a crucial strategy employed by intracellular pathogens enclosed within vacuoles to access the nutrient-rich cytosol for intracellular replication.
Léa Swistak +13 more
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Systematic Analysis of the Stress-Induced Genomic Instability of Type Three Secretion System in Aeromonas salmonicida subsp. salmonicida [PDF]
Microorganisms, 2020 The type three secretion system (TTSS) locus of Aeromonas salmonicida subsp. salmonicida, located on the plasmid pAsa5, is known to be lost when the bacterium is grown at temperatures of 25 °C.
Pierre-Étienne Marcoux +10 more
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