The Shigella type three secretion system effector OspG directly and specifically binds to host ubiquitin for activation. [PDF]
PLoS ONE, 2013 The genus Shigella infects human gut epithelial cells to cause diarrhea and gastrointestinal disorders. Like many other Gram-negative bacterial pathogens, the virulence of Shigella spp.
Yan Zhou, Na Dong, Liyan Hu, Feng Shao
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Type I secretion system—it takes three and a substrate [PDF]
FEMS Microbiology Letters, 2018 Type I secretion systems are widespread in Gram-negative bacteria and mediate the one-step translocation of a large variety of proteins serving for diverse purposes, including nutrient acquisition or bacterial virulence. Common to most substrates of type I secretion systems is the presence of a C-terminal secretion sequence that is not cleaved during ...
Kerstin Kanonenberg +4 more
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DksA coordinates bile-mediated regulation of virulence-associated phenotypes in type three secretion system-positive Vibrio cholerae. [PDF]
Microbiology (Reading), 2021 Sofia MK, Dziejman M.
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Spa47 is an oligomerization-activated type three secretion system (T3SS) ATPase from Shigella flexneri. [PDF]
Protein Sci, 2016 Burgess JL +6 more
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Novel Noncompetitive Type Three Secretion System ATPase Inhibitors Shut Down Shigella Effector Secretion. [PDF]
Biochemistry, 2020 Shigella is the causative agent of bacillary dysentery and is responsible for an estimated 165 million infections and 600,000 deaths annually. Like many Gram-negative pathogens, Shigella relies on a type three secretion system (T3SS) to initiate and sustain infection by directly injecting effector proteins into host cells. Protein secretion through the
Case HB +3 more
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Global Analysis of Type Three Secretion System and Quorum Sensing Inhibition of Pseudomonas savastanoi by Polyphenols Extracts from Vegetable Residues. [PDF]
PLoS One, 2016 Biancalani C +6 more
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SrcA is a chaperone for the Salmonella SPI-2 type three secretion system effector SteD. [PDF]
Microbiology (Reading), 2019 Godlee C, Cerny O, Durkin CH, Holden DW.
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Assembly and arrangement of the type three secretion system of "yersinia enterocolitica"
, 2014 The type three secretion system (T3SS) is a bacterial weapon found in many Gram-negative bacteria. It consists out of a needle like structure called injectisome, which enables bacteria to inject effector proteins into eukaryotic cells. The injectisome is a very complex molecular machine, inserted in the inner and outer bacteria membrane, passing the ...
Marlise Amstutz
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Shutting Down Shigella Secretion: Characterizing Small Molecule Type Three Secretion System ATPase Inhibitors. [PDF]
Biochemistry, 2018 Many important human pathogens rely on one or more type three secretion systems (T3SSs) to inject bacterial effector proteins directly into the host cell cytoplasm. Secretion of protein through the needlelike type three secretion apparatus (T3SA) is essential for pathogen virulence and relies on a highly conserved ATPase at the base of the apparatus ...
Case HB, Mattock DS, Dickenson NE.
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YM155 Inhibits NleB and SseK Arginine Glycosyltransferase Activity
Pathogens, 2021 The type III secretion system effector proteins NleB and SseK are glycosyltransferases that glycosylate protein substrates on arginine residues. We conducted high-throughput screening assays on 42,498 compounds to identify NleB/SseK inhibitors.
Congrui Zhu +4 more
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