Repurposing Avasimibe to Inhibit Bacterial Glycosyltransferases
Pathogens, 2022 We are interested in identifying and characterizing small molecule inhibitors of bacterial virulence factors for their potential use as anti-virulence inhibitors.
Md Kamrul Hasan +4 more
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MxiN Differentially Regulates Monomeric and Oligomeric Species of the Shigella Type Three Secretion System ATPase Spa47. [PDF]
Biochemistry, 2018 Case HB, Dickenson NE.
europepmc +2 more sources
mSphere, 2023 Pathogenesis of Pseudomonas aeruginosa infections can include bacterial survival inside epithelial cells. Previously, we showed that this involves multiple roles played by the type three secretion system (T3SS), and specifically the effector ExoS.
Abby R. Kroken +6 more
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Cross-talk between Type Three Secretion System and Metabolism in Yersinia [PDF]
Journal of Biological Chemistry, 2009 The journal of biological chemistry 284, 12165-77 (2009).
Schmid, Annika +12 more
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Exploration of chlamydial type III secretion system reconstitution in Escherichia coli. [PDF]
PLoS ONE, 2012 BACKGROUND:Type III secretion system is a virulent factor for many pathogens, and is thought to play multiple roles in the development cycle and pathogenesis of chlamydia, an important human pathogen.
Xiaofeng Bao +2 more
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Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target. [PDF]
EcoSal Plus, 2019 Antibiotic resistance is a major public health threat that has stimulated the scientific community to search for nontraditional therapeutic targets. Because virulence, but not the growth, of many Gram-negative bacterial pathogens depends on the multicomponent type three secretion system injectisome (T3SSi), the T3SSi has been an attractive target for ...
Fasciano AC, Shaban L, Mecsas J.
europepmc +4 more sources
Type Three Secretion System in Pseudomonas savastanoi Pathovars: Does Timing Matter? [PDF]
Genes, 2011 Pseudomonas savastanoi pv. savastanoi is the causal agent of Olive knot disease, relying on the Type Three Secretion System (TTSS) for its pathogenicity. In this regard, nothing was known about the two other pathovars belonging to this species, pv. nerii and pv. fraxini, characterized by a different host range. Here we report on the organization of the
Tegli S +4 more
openaire +6 more sources
Salmonella entericaReplication in Hemophagocytic Macrophages Requires Two Type Three Secretion Systems [PDF]
Infection and Immunity, 2010 ABSTRACTSalmonella entericaserotype Typhimurium is a natural pathogen of mice, which acquire the bacteria orally and develop systemic acute infections that can become subacute to chronic infections.S.Typhimurium can reside within hemophagocytic macrophages (HMs) in SV129S6 mice, an Slc11a1/Nramp1+/+inbred strain.
Eugenia Silva‐Herzog +1 more
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Acta Medica Iranica, 2020 Pseudomonas aeruginosa (P. aeruginosa) is a common bacteria associated with burn infections and resistance to a wide range of disinfectants and antimicrobial agents which is able to produce different virulence factors.
Mehdi Rahmati +2 more
doaj +1 more source
Expression and Quorum Sensing Regulation of Type III Secretion System Genes of Vibrio harveyi during Infection of Gnotobiotic Brine Shrimp. [PDF]
PLoS ONE, 2015 Type III secretion systems enable pathogens to inject their virulence factors directly into the cytoplasm of the host cells. The type III secretion system of Vibrio harveyi, a major pathogen of aquatic organisms and a model species in quorum sensing ...
H A Darshanee Ruwandeepika +3 more
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