Results 171 to 180 of about 2,607 (202)

Production of the entire extracellular domain of BP180 (type XVII collagen) by baculovirus expression

Journal of Dermatological Science, 2000
Bullous pemphigoid (BP) is an acquired autoimmune skin disease, and its target antigens are a 230 kDa plaque protein (BP230) and a 180 kDa transmembrane protein with interrupted collagenous domains (BP180, type XVII collagen), which localize at the hemidesmosome.
Y, Hata, Y, Fujii, K, Tsunoda, M, Amagai
openaire   +2 more sources

Pigmentation and melanocyte supply to the epidermis depend on type XVII collagen

Experimental Dermatology, 2014
Genetic deficiency of type XVII collagen (C17), laminin-332 or type VII collagen causes epidermolysis bullosa (EB). Spontaneous correction of the deficiency, also known as revertant mosaicism, is caused by a second somatic mutation that restores protein expression resulting in clinically healthy (revertant) patches surrounded by fragile (mutant) skin ...
Gostynski, Antoni, Pasmooij, Anna M. G., Del Rio, Marcela, Diercks, Gilles F., Pas, Hendrikus, Jonkman, Marcellinus   +5 more
openaire   +1 more source

Discovery and Functional Characterization of a Recombinant Fragment of Human Collagen Type XVII

Journal of Agricultural and Food Chemistry
COL17A1 is predominantly expressed in skin epithelial cells and primarily localized within hemidesmosomes. It plays an essential role in epidermal-dermal attachment. Consequently, a recombinant human-like COL17A1 protein (rhCOL17) with low molecular weight and high biocompatibility presents a promising and competitive biomaterial. The aim of this study
Lianhua Piao, Jiajia Li, Xiaojing Li, Yangyang Su, Xiaofeng Yuan, Shan Chang, Xinyi Cheng, Shengwei Fu, Ren Kong   +8 more
openaire   +2 more sources

Two type XVII collagen (BP180) mRNA transcripts in human keratinocytes: a long and a short form.

Clinical and experimental dermatology, 2000
We have analysed BP180 mRNA expression in normal human keratinocytes. Here we report the presence in normal keratinocytes of two COL17A1 transcripts which differ by 0.6 kb in length. Both mRNAs hybridized on Northern blot with probes directed to sequences encoding intracellular and extracellular fragments of BP180.
Molnar, K, van der Steege, G, Jonkman, MF, Nijenhuis, Albertine, Husz, S, van der Meer, JB, Pas, HH   +6 more
openaire   +2 more sources

Collagen type XVII

1998
S AYAD, R BOOTHANDFORD, M HUMPHRIES, K KADLER, A SHUTTLEWORTH   +4 more
openaire   +2 more sources

BP180 (type XVII collagen) and its role in cutaneous biology and disease.

Advances in dermatology, 2003
BP180 is a key component of the epidermal anchoring complex and functions to maintain adherence of the epidermis to the basement membrane. Structural studies have revealed that BP180 is a type II transmembrane protein with a long carboxy-terminal collagenous domain that projects into the extracellular region beneath the epidermal hemidesmosome.
Françoise, Van den Bergh, George J, Giudice   +1 more
openaire   +1 more source

Type XVII Collagen

2016
S. Sun, M.A. Karsdal
openaire   +1 more source

Type 2 chronic inflammatory diseases: targets, therapies and unmet needs

Nature Reviews Drug Discovery, 2023
P V Kolkhir, Thomas Bieber, E Guttman-Yassky   +2 more
exaly  

Collagen type XVII (α1 chain)

2000
Clare M. Isacke, Michael A. Horton
openaire   +1 more source

Cleavage of BP180 (type XVII collagen) yields a 120 KDA collagenous extracellular polypeptide

Journal of Dermatological Science, 1998
Y. Hirako, J. Usukura, J. Uematsu, T. Hashimoto, Y. Kitajima, K. Owaribe   +5 more
openaire   +1 more source